血清CA19-9、CEA水平与胰腺癌预后的关系
| 作者: |
1吴蕾,
1黄珮珺,
1王芳,
1李大千,
1谢而付,
1张燕,
1潘世扬
1 南京医科大学第一附属医院检验学部，南京 210029 |
| 通讯: |
吴蕾
Email: leiwu90@163.com 潘世扬 Email: panshiyang64@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.03.013 |
| 基金: | 国家自然科学基金, 81371894，81302531，81272324，81201359，81101322 江苏省实验诊断学重点实验室, XK201114 江苏高校优势学科建设工程基金项目 |
摘要
目的：探讨胰腺癌患者术前血清中CA19-9与CEA表达情况对预后的影响。方法：回顾分析医院 2012年1月~2013年12月128例胰腺癌患者临床病理资料，应用Kaplan-Meier法、Log-rank检验及Cox 回归分析CA19-9和CEA水平与患者生存时间的关系。血清中CA19-9 >39 U/mL，CEA >4.7 ng/mL被 视为表达增高。结果：128例患者平均年龄为62岁，中位生存期为12.2月，其中CA19-9和CEA的表达 水平增高的比例分别为78.1%，37.5%。CA19-9、CEA升高组患者的预后明显差于正常组(CA19-9， P=0.027；CEA，P=0.036)。Cox多因素回归分析显示淋巴结转移、CA19-9 >39 U/mL、CEA >4.7 ng/mL 是影响胰腺癌患者预后的独立因素。结论：术前CA19-9、CEA水平与胰腺患者生存时间密切相关， 能有效评估患者的预后。
关键词：
胰腺癌
CA19-9
CEA
预后
Relationship between serum CA19-9, CEA levels and prognosis for patients with pancreatic cancer
CorrespondingAuthor: WU Lei Email: leiwu90@163.com
DOI: 10.3978/j.issn.2095-6959.2015.03.013
Abstract
Objective: To explore the use of preoperative CA19-9 and CEA serum levels as prognostic factors to affect survival in pancreatic cancer. Methods: A retrospective review of the clinical records of 128 patients with pancreatic adenocarcinoma between January, 2012 and December, 2013 was performed. Kaplan-Meier method, log-rank test and Cox regression analysis models were used to investigate the relationship between the levels of CA19-9 and CEA and survival outcome. The cut-off for CA19-9, CEA was 39 U/mL and 4.7 ng/mL. Results: The mean age of 128 patients was 62 years, and the median survival time was 12.2 months. The positive rate of CA19-9 and CEA were respectively 78.1%, 37.5%. Patients with high CA19-9 or CEA levels suffered a poorer prognosis than the individuals with normal levels (CA19-9, P=0.027; CEA, P=0.036). Cox logistic analysis revealed that lymphatic metastasis, CA19-9 >39 U/mL and CEA >4.7 ng/mL were independent prognostic factors. Conclusion: The serum levels of preoperative CA19-9 and CEA were significant associated with survival time of pancreatic cancer patients, and could evaluate the prognosis of these patients.