性激素水平与女性乳腺癌的相关性研究
| 作者: |
1王娟娟,
1古雨浓,
1李建,
1刘斌
1 延安大学附属医院普外科，陕西 延安 716000 |
| 通讯: |
刘斌
Email: liubin070806@sohu.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.06.044 |
摘要
目的：本研究旨在探讨本地区部分女性性激素水平与乳腺癌发生的关系，为高危人群的发现、疾病控制策略的制定以及针对性的药物研发提供科学依据。方法：2013年1月至2015年1月，本研究从延安大学附属医院收集研究对象，按照乳腺疾病状态分为乳腺癌组(72例)和健康对照组(93例)。数据处理使用SPSS22.0，比较研究对象的一般资料及性激素水平差异，同时按照四分位数将各激素水平分为四个层次，以P25组水平作为参照组，进行非条件Logistic回归分析。结果：按照四分位数将各激素水平分为四个层次，与P25组睾酮水平相比较，P25~P50组的黄体期女性其乳腺癌风险有上升；P75组的卵泡期及绝经后期女性其乳腺癌风险显著上升。以P25组雌二醇水平为参照组，P50~P75组的黄体期女性其乳腺癌风险有上升；P75组的卵泡期、黄体期及绝经后期女性其乳腺癌风险显著上升。与P25组孕酮水平相比较，P50~P75组的黄体期女性其乳腺癌风险有上升；P75组的黄体期女性其乳腺癌风险显著上升。同时对不同暴露水平进行趋势卡方检验的结果显示，绝经后期女性其乳腺癌发生风险随着睾酮水平的上升显著增加(Ptrend=0.027)。卵泡期、黄体期及绝经后期女性乳腺癌发生风险随着雌二醇水平的上升显著增加(Ptrend=0.032、0.039、0.041)。黄体期女性其乳腺癌的发生风险随着孕酮水平的上升显著增加(Ptrend=0.011)。结论：通过对本地区部分女性的调查分析，发现绝经后期女性乳腺癌发生风险随着睾酮水平的上升显著增加；卵泡期、黄体期及绝经后期女性乳腺癌发生风险随着雌二醇水平的上升显著增加；黄体期女性其乳腺癌的发生风险随着孕酮水平的上升显著增加。
关键词：
乳腺癌
睾酮
雌二醇
孕酮
The study on the association of sex steriod hormone levels with the risk of breast cancer
CorrespondingAuthor: LIU Bin Email: liubin070806@sohu.com
DOI: 10.3978/j.issn.2095-6959.2015.06.044
Abstract
Objective: The purpose of the study is to explore the association of sex steroid hormone levels with risk of breast cancer, in order to breast cancer prevention and treatment and provide a theoretical basis. Methods: From Jan 2013 to Jan 2015 in urban Yan’an, was carried out to assess the relationship between sex steroid hormone and risk of breast cancer. Subjects were divided into the breast cancer (72 cases) and control group (93 cases) according to their disease status. Software SPSS 22.0 was applied to analyze the difference of conventional risk factors and sex hormone levels among different groups. All statistical tests were two-sides. Results: We observed that increased risks of breast cancer were positively associated with elevated concentration of testosterone for highest vs. lowest quartile in follicle phase and postmenopausal period. Increased risks of breast cancer were positively associated with elevated concentration of estrodiol for highest vs. lowest quartile in follicle phase, luteal phase and postmenopausal period. Increased risks of breast cancer were positively associated with elevated concentration of progesterone for highest versus lowest quartile in luteal phase. Increased risks of breast cancer were positively associated with elevated concentration of testosterone in postmenopausal women (Ptrend=0.027). Increased risks of breast cancer were positively associated with elevated concentration of estrodiol in follicle phase, luteal phase and postmenopausal (Ptrend=0.032, 0.039, 0.041). Increased risks of breast cancer were positively associated with elevated concentration of progesterone in luteal phase (Ptrend=0.011). Conclusion: Our study investigated the risk factors of breast cancer in Yan’an, Shaanxi, evaluated the associations of sex hormone levels with breast cancer risk. Increased risks of breast cancer were positively associated with elevated concentration of testosterone in postmenopausal women. Increased risks of breast cancer were positively associated with elevated concentration of estrodiol in follicle phase and luteal phase. Increased risks of breast cancer were positively associated with and elevated concentration of progesterone in luteal phase.