Objective: To investigate the clinicopathologic characteristics of dendritic fibromyxolipoma for the purpose of differentiating it from other confusable soft tissue neoplasms. Methods: The clinicopathologic features in 5 cases of DFML were collected. Their clinicopathological histologic characteristics and immunophenotypes were analyzed. Results: The patients were middle-aged to elderly men, which between 45 and 80 years of age. The tumors were located in the subcutaneous tissues or muscular fascia of the neck region, back and shoulder. The main clinical manifestations were local mass and pressure symptom. The diameter of DFMLs was between 3 and 8 cm and clear edge in DFMLs. Grossly, it is circular or nearly-circular, partly thinly encapsulated lesion with focal mucinous or gelatinous cutting which presented yellowish. Histologically, the tumor was characterized by an admixture of mature adipocytes, spindle and stellate cells and abundant myxoid stroma. At high magnification, the tumor cells showed thin cytoplasmic dentritic prolongations, and no cytological atypia or mitotic activity could be identified. Furthermore, the lesions were rich in plexiform small blood vessels and capillaries. Immunohistochemical results showed that tumor cells were positive for vimentin, CD34 and BCL-2, negative for S-100 and CK, less than 2% positive rate or negative for Ki67. Conclusion: Dendritic fibromyxolipoma is a special variant of lipoma with a predilection for middle to old aged males, whose pathological features were closely similar to other soft tissue tumors, such as spindle cell lipoma. Its biological behavior is benign, and immunohistochemical staining is helpful to the diagnosis and differential diagnosis.