血清YKL-40蛋白水平与非肌层浸润性膀胱癌复发的临床关系研究
| 作者: |
1严佳胜,
1申佩军,
1郑军华,
1刘敏
1 同济大学附属第十人民医院泌尿外科，上海 200072 |
| 通讯: |
严佳胜
Email: yanjiashengshsy@163.com 郑军华 Email: zhengjh0471@sina.com 刘敏 Email: kidneyliu@vip.163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.04.016 |
| 基金: | 槲皮素调控Erbin/Nod2/NF-κB通路防治肾脏缺血再灌注损伤的实验研究, 14ZR1432300 |
摘要
目的：探讨患者血清YKL-40蛋白水平与非肌层浸润性膀胱癌(non muscle-invasive bladder cancer， NMIBC)复发的临床关系。方法：选取76例NMIBC患者，其中34例为术后随访两年内确诊复发患 者、42例为术后随访两年未见复发患者，及健康对照组31例，采取清晨血清样本，采用酶联接免 疫吸附剂测定法(ELISA)检测患者血清中YKL-40水平。结果：NMIBC患者血清YKL-40水平显著 高于健康对照组(P<0.001)，同时，NMIBC复发组患者血清YKL-40水平高于非复发组(P=0.001)。 结论：血清YKL-40蛋白水平在非肌层浸润性膀胱癌复发中有着较高的临床诊断价值，可作为监测 患者术后复发的一种新分子标志物，为患者术后相关后续治疗提供参考。
关键词：
YKL-40
非肌层浸润性膀胱癌
复发
血清
Clinical correlation between serum YKL-40 protein level and the recurrence of non muscle-invasive bladder cancer
CorrespondingAuthor: YAN Jiasheng Email: yanjiashengshsy@163.com
DOI: 10.3978/j.issn.2095-6959.2015.04.016
Abstract
Objective: The aim of this study was to further understand the correlation between serum YKL-40 protein level and recurrence of non muscle-invasive bladder cancer (NMIBC). Methods: Totally, 76 patients of NMIBC and 31 healthy volunteers were recruited in this study. After two years follow-up, 34 patients were found with recurrence by cystoscope. Serum YKL-40 protein levels of all these patients were analysed by using Enzymelinked immunosorbent assay (ELISA) methods. Data analyses and ROC curve were performed in SPSS. All values are two tailed. Results: Serum YKL-40 protein levels were significantly higher in patients with bladder cancercompared with controls (P<0.001). Serum YKL-40 protein levels were found to be higher in patients with recurrent NMIBC compared with patients with non recurrent bladder cancer (P=0.001). Conclusion: Serum YKL-40 protein could be a reliable molecular marker for diagnosis of recurrence of NMIBC. Serum YKL-40 protein level could provide a good value of guide for postoperative treatment.