生长因子用于软骨修复的研究进展
| 作者: |
1胡伟全,
1赵建宁,
1徐海栋,
1张雷
1 南京大学医学院临床学院(南京军区南京总医院) 骨科，南京 210093 |
| 通讯: |
胡伟全
Email: bing00quan@163.com 赵建宁 Email: zhaojianning.0207@163.com 徐海栋 Email: xuhaidong1980@163.com 张雷 Email: ra_eagle@hotmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.03.027 |
| 基金: | 江苏省临床医学科技专项资助, BL2012002 南京市科研课题, 201402007 |
摘要
各种原因导致的关节软骨损伤或软骨退行性变是临床的常见病，目前尚缺乏有效的治疗方法。随 着组织工程技术的发展，组织工程为软骨损伤修复提供了新的方法。生长因子是软骨组织工程的 一个基本要素，近年来已成为软骨修复的研究热点，其在软骨形成和软骨细胞基质的合成、代谢 方面发挥重要的作用。本文就转录生长因子-β、骨形态发生蛋白、胰岛素样生长因子等的最新研 究做一综述，以期发现理想的生长因子及其组合用于促进软骨修复。
关键词：
软骨修复
细胞因子
综述
Research advances of growth factors in cartilage repair
CorrespondingAuthor: HU Weiquan Email: bing00quan@163.com
DOI: 10.3978/j.issn.2095-6959.2015.03.027
Abstract
Articular cartilage injury and degeneration, caused by a variety of reasons, is a common disease in clinic and lack of effective therapy so far. Yet with the development of tissue engineering, a new method is gradually applied for the cartilage renovation. Growth factor, as a basic factor of cartilage tissue engineering, have been a hot spot in recent researches, since it plays a significant role in not only chondrogenesis but also the formation of matrix and metabolism of cartilage chondrocyte. This article reviews the current advances of transforming growth factor-β, bone morphogenetic protein, insulin growth factor to find ideal growth factors as well as their combinations, in order to promote the cartilage renovation.