枕骨大孔-第二颈段血管周细胞瘤1例报道并文献复习
| 作者: |
1刘翠,
1许春伟,
1张博,
1邵云,
1姜春婷,
1王怀涛,
1王海艳,
1吴永芳,
1李晓兵,
1张彤
1 军事医学科学院附属医院理科，北京 100071 |
| 通讯: |
刘翠
Email: 1085791582@qq.com 许春伟 Email: xuchunweibbb@163.com 张博 Email: zenwo@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.03.032 |
摘要
目的：探讨血管周细胞瘤的临床病理学特点及诊断要点。方法：对1例血管周细胞瘤进行临床资 料、病理形态学及免疫组化观察，并结合文献对其诊断及鉴别诊断进行探讨。结果：本例镜下观 肿瘤细胞为梭形，血管丰富，形成弥漫的网状结构，鹿角状的血管将肿瘤细胞分割小叶状，瘤细 胞体积较大，胞浆丰富，边界不清，核呈圆形、卵圆形，病理性核分裂相多。免疫组化染色结果 显示肿瘤细胞Vimentin(+)、CD34(+)、FVIII(+)、S-100(−)、CEA(−)和GFAP(−)。结论：血管周 细胞瘤，非常少见，因此缺乏对其认识，从而易与其他肿瘤混淆导致误诊。提高对血管周细胞瘤 的认识，对避免误诊是至关重要的。
关键词：
血管周细胞瘤
病理学
临床
免疫组化
A case report and literature review on foramen magnum- the second cervical segment hemangiopericytoma
CorrespondingAuthor: LIU Cui Email: 1085791582@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.03.032
Abstract
Objective: To explore the characteristics of clinicopathology and diagnostic criteria about hemangiopericytoma. Methods: The clinical data, histopathologic observation and immunohistochemical staining were studied in one case of foramen magnum- the second cervical segment hemangiopericytoma, in order to explore its diagnosis and differential diagnosis combined with literatures. Results: Microscopic examination of this case showed that the tumor cells were fusiform with rich blood vessels and they formed a diffuse network structures. Tumor cells were segmentation into lobular structures by staghorn blood vessels. Tumor cells were large, abundant cytoplasm, ill-defined, and nuclei were round or oval with pathological mitoses. Immunohistochemical staining showed that the tumor cells were Vimentin(+), CD34(+), FVIII(+), S-100(−), CEA(−) and GFAP(−). Conclusion: Hemangiopericytoma is very rare and lack of awareness, thus easily confused with other tumor leading to misdiagnosis. It is essential to avoid misdiagnosis with raising awareness.