胃间质瘤的腹腔镜手术治疗及临床疗效分析
| 作者: |
1薛勇敢,
1李鹏,
1贾宝庆,
1张秉栋,
1张加金
1 解放军总医院肿瘤外一科，北京 100853 |
| 通讯: |
薛勇敢
Email: yongganxue@126.com 李鹏 Email: doctorlipeng@126.com 贾宝庆 Email: baoqingjia@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.02.016 |
| 基金: | RACK1调控细胞凋亡在结直肠癌发生发展中的作用研究, 81171901 |
摘要
目的:探讨腹腔镜手术治疗胃间质瘤的可行性及安全性。
方法:回顾分析解放军总医院肿瘤外科2010 年3月至2014 年9月期间经腹腔镜手术治疗的50例 胃间质瘤患者的临床资料。
结果:平均手术时间为(105.7±59.0 ) min，术中出血为(50±53.9 ) ml；术后进食清流食时间为(4.6±1.8) d，术后平均住院时间为(8.7±6.2) d，无手术死亡病例。病理切缘均为阴性，肿瘤直径为1.0～16.0 cm，中位直径5.6 cm。CD34阳性者45例(90.0％) ，CD117阳性者42例 (84.0％) ，S-100 阳性者5例(10.0％)。中位随访23.3(1～55)个月， 1例 术后12个月发现肝转移，无再次手术及死亡病例。
结论:对于胃间质瘤，腹腔镜手术是一种安全、有效的治疗方式，肿瘤大小并不是手术绝对禁忌症。
关键词：
胃间质瘤
腹腔镜
手术治疗
方法:回顾分析解放军总医院肿瘤外科2010 年3月至2014 年9月期间经腹腔镜手术治疗的50例 胃间质瘤患者的临床资料。
结果:平均手术时间为(105.7±59.0 ) min，术中出血为(50±53.9 ) ml；术后进食清流食时间为(4.6±1.8) d，术后平均住院时间为(8.7±6.2) d，无手术死亡病例。病理切缘均为阴性，肿瘤直径为1.0～16.0 cm，中位直径5.6 cm。CD34阳性者45例(90.0％) ，CD117阳性者42例 (84.0％) ，S-100 阳性者5例(10.0％)。中位随访23.3(1～55)个月， 1例 术后12个月发现肝转移，无再次手术及死亡病例。
结论:对于胃间质瘤，腹腔镜手术是一种安全、有效的治疗方式，肿瘤大小并不是手术绝对禁忌症。
Analysis of Laparoscopic Surgical Treatment for gastric stromal tumors
CorrespondingAuthor: XUE Yonggan Email: yongganxue@126.com
DOI: 10.3978/j.issn.2095-6959.2015.02.016
Abstract
Objective: To identify the technical feasibility and oncologic safety of laparoscopic surgery in the treatment of gastric stromal tumors.
Methods: Between March, 2010 and September, 2014, clinical data of 50 patients undergoing laparoscopic treatment of gastric stromal tumors in the Department of Oncologic Surgery, Chinese People’s Liberation Army General Hospital were retrospectively analyzed.
Results: Mean operative time was (105.7±59.0 ) min, the mean blood loss was (50±53.9 ) mL, the initiate fluid intake was (4.6±1.8) d and the mean postoperative hospital stay was (8.7±6.2) d. There was no operative mortality. All lesions had negative resection margins. The resected tumor was 1.0～16.0 cm in diameter, mean size 5.6cm. 45 patients were CD34 positive (90.0％) , 42 patients were CD117positive(84.0％) and 5 patients were S-100 positive (10.0％). During a mean follow-up period of 23.3 (range, 5～55) months, only one patients experienced liver metastasis 12 months after operation. There were no re-operation and death.
Conclusion：The laparoscopic surgery is safe and effective in treating gastric stromal tumors, tumor size was not the absolutely operative contraindication.
Methods: Between March, 2010 and September, 2014, clinical data of 50 patients undergoing laparoscopic treatment of gastric stromal tumors in the Department of Oncologic Surgery, Chinese People’s Liberation Army General Hospital were retrospectively analyzed.
Results: Mean operative time was (105.7±59.0 ) min, the mean blood loss was (50±53.9 ) mL, the initiate fluid intake was (4.6±1.8) d and the mean postoperative hospital stay was (8.7±6.2) d. There was no operative mortality. All lesions had negative resection margins. The resected tumor was 1.0～16.0 cm in diameter, mean size 5.6cm. 45 patients were CD34 positive (90.0％) , 42 patients were CD117positive(84.0％) and 5 patients were S-100 positive (10.0％). During a mean follow-up period of 23.3 (range, 5～55) months, only one patients experienced liver metastasis 12 months after operation. There were no re-operation and death.
Conclusion：The laparoscopic surgery is safe and effective in treating gastric stromal tumors, tumor size was not the absolutely operative contraindication.