Notch信号通路在脑缺血的研究进展
| 作者: |
1周强,
1李朝晖
1 暨南大学附属珠海医院, 珠海市人民医院神经内科, 广东 珠海 519000 |
| 通讯: |
周强
Email: astrosky@126.com 李朝晖 Email: 2478863904@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.03.023 |
| 基金: | 国家卫生计生委脑卒中筛查与防治工程项目 |
摘要
Notch信号通路对中枢神经系统、血管细胞及免疫细胞生长分化发挥重要的调节作用。脑血管疾病 引起的脑缺血激活Notch信号通路，活化的Notch信号通路调控神经前体细胞增殖和分化、介导炎 症介质释放和促进血管细胞生成等在神经损伤修复、炎症反应、血管缺血区血管生成等起重要的 调节作用。此外，Notch还与遗传性疾病CADASIL发病有关。本文就Notch信号通路在脑血管病中 的作用及机制进行了分析。
关键词：
Notch信号通路
脑血管疾病
神经损伤修复
血管生成
The advance of notch signal-pathway in cerebral ischemia
CorrespondingAuthor: ZHOU Qiang Email: astrosky@126.com
DOI: 10.3978/j.issn.2095-6959.2015.03.023
Abstract
Notch signal-pathway exerts a significance regulatory role in central nervous system, vascular cells, and immune cell. Notch signal-pathway activated by cerebral ischemia regulates nerve damage repair, inflammation, and angiogenesis in vascular ischemia area through regulating the proliferation and development of neuronal precursor cell, mediating inflammatory factors releasing, and promote angiogenesis. Additionally, Notch signal-pathway is associated with the development of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy. In the present, the mechanism of notch signal-pathway involved in cerebrovascular disease is analyzed.