NLRP3炎性小体在动脉粥样硬化发生发展中的作用
| 作者: |
1甘祥海,
1吕湛
1 川北医学院附属医院心血管内科，四川南充 637000 |
| 通讯: |
甘祥海
Email: 34588712@qq.com 吕湛 Email: doctor_lz@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.03.025 |
摘要
NLRP3炎性小体是一种包含胞内受体(主要是NOD样受体)、半胱天冬氨酸前体和凋亡相关斑点 样蛋白的蛋白质复合体。该复合体最初只是被描述为一种影响感染和炎症过程的复合体，它的活 化引起半胱天冬氨酶-1的激活并剪切加工底物白细胞介素-1β(interleukin-1β，IL-1β)和白细胞介 素-18(interleukin-18，IL-18)，从而引起炎症反应；此外，炎性小体的激活过程对有氧糖酵解(瓦伯 格效应，Warburg effect)有着重要的影响，这同样可以促进炎症的发生。随后的证据表明炎性小体 的活化还影响很多代谢紊乱包括动脉粥样硬化(atherosclerosis, AS)、2型糖尿病、痛风和肥胖等。 本综述将探讨AS与炎症、NLRP3炎性小体活化的关联性，以及瓦伯格效应如何关联炎症反应及炎 性小体的激活。
关键词：
NLRP3炎性小体
白细胞介素-1β
半胱天冬氨酶-1
动脉粥样硬化
NLRP3 inflammasome role in the occurrence and development of atherosclerosis
CorrespondingAuthor: GAN Xianghai Email: 34588712@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.03.025
Abstract
The NLRP3 inflammasome is a protein complex that includes an intracellular sensor (mainly a NOD-like receptor), the precursor procaspase-1 and the adaptor ASC. Initially the inflammasome was described as a complex which influences infection and inflammation. Inflammasome activation leads to the maturation of caspase-1 and the process of its substrates, interleukin-1β (IL-1β) and interleukin-18 (IL-18), which leads to inflammatory response. Moreover, another feature of inflammation is that the process of activating inflammasome has a significant effect on aerobic glycolysis (“Warburg effect”). Subsequent evidences have suggested that inflammasome activation affects many metabolic disorders, including atherosclerosis (AS), type 2 diabetes, gout and obesity. We will discuss the relationship among AS, inflammation and NLRP3 inflammasome activation, and how the Warburg effect may link to inflammation and inflammasome activation in this review.