回肠B细胞淋巴瘤合并戊型肝炎一例临床分析
| 作者: |
1刘燕翔,
2郭凌川,
2郑玉双,
3胥萍,
4沈兴华,
1杜明伟
1 苏州市第五人民医院病理科，苏州 215007 2 苏州大学附属第一人民医院病理科，苏州 215007 3 苏州市第五人民医院 检验中心，苏州 215007 4 苏州市第五人民医院 重症病区，苏州 215007 |
| 通讯: |
刘燕翔
Email: liu-yanxiang@foxmail.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.02.036 |
摘要
目的：探讨回肠B细胞淋巴瘤合并戊型肝炎(hepatitis E virus，HEV)的诊断及治疗，提高对淋巴瘤 合并病毒性肝炎的认识。方法：回顾性分析收治的一例回肠B细胞淋巴瘤合并HEV的临床特点、组 织病理学特征及HEV的诊断及治疗过程，并复习相关文献。结果：组织病理学及免疫组织化学染 色诊断为回肠粘膜相关淋巴组织淋巴瘤(mucosa associated lymphoid tissue lymphoma，MALT)伴弥 漫大B细胞淋巴瘤(diffuse large B cell lymphoma，DLBCL)转化。血清学方法诊断为HEV。结论：回 肠B细胞淋巴瘤合并HEV少见，肿块切除并同时进行保肝退黄等对症治疗有助于明确诊断及肝功能 好转。
关键词：
淋巴瘤
戊型肝炎
回肠
Clinical analysis of one case ileal B-cell type lymphoma with hepatitis E virus
CorrespondingAuthor: LIU Yanxiang Email: liu-yanxiang@foxmail.com
DOI: 10.3978/j.issn.2095-6959.2015.02.036
Abstract
Objective: To investigate the clinical diagnosis and treatment of ileal B-cell type lymphoma with hepatitis E virus (HEV) and to improve the understanding of B-cell type lymphoma with hepatitis virus and to provide reference for treatment. Methods: One case of ileal B-cell type lymphoma with HEV was analyzed by clinical feature, pathological characters, diagnosis and treatment of HEV in our hospital, and meanwhile the related literatures were reviewed. Results: Histopathology and immunohistochemical findings revealed that most of tumor cells were widely positively stained for CD20 and CD79a, but negative for MuM1 CyclinD1 Bcl-6 and CD5. It was diagnosed ileal mucosa associated lymphoid tissue lymphoma (MALT) and transform to diffuse large B cell lymphoma (DLBCL), and was diagnosed HEV by serological methods. Conclusion: Ileal B-cell type lymphoma with HEV is extremely rare, ileectomy is helpful for diagnosis, symptomatic treatment of HEV is helpful liver function improved.