骨形态发生蛋白2(BMP-2)诱导血管钙化相关机制的新进展
| 作者: |
1李岚,
1刘江华,
1祖旭宇,
1伍莹
1 南华大学附属第一医院，湖南衡阳 421001 |
| 通讯: |
刘江华
Email: jianghua990@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.05.033 |
摘要
研究表明血管钙化是一个类似成骨的主动、可预防和可逆转的高度可调控的生物学过程。骨形 态发生蛋白(bone morphogenetic proteins，BMPs)家族作为转化生长因子β(transforming growth factor-β，TGF-β)超家族的成员，因具有诱导骨形成的特点而得名，到目前为止，已发现30余 种BMP成员,其中BMP-2是一类唯一能够单独诱导骨组织形成的局部生长因子。目前有关动脉粥 样硬化及血管钙化中BMP-2作用机制的研究日益增多。本文就近年BMP-2诱导动脉钙化(arterial calcification，AC)的相关研究进展作一综述。
关键词：
骨形态发生蛋白(BMP-2)
血管钙化
microRNA
细胞凋亡
蛋白C-羧基谷氨酸基质蛋白(MGP)
New progress between bone morphophonemic protein 2 (BMP-2) and vascular calcification
CorrespondingAuthor: LIU Jianghua Email: jianghua990@126.com
DOI: 10.3978/j.issn.2095-6959.2014.05.033
Abstract
Vascular calcification is an initiative, preventable, reversible and highly regulated processes as same as osteoblasts biological. Bone morphogenetic proteins (bone morphogenetic proteins, BMPs) families are members of transforming growth factor β (TGF-β) super family, because the characteristics of induced bone formation has named. Now, more than 30 species have been found, BMP-2 is a kind of local growth factor which is the only one can induce bone formation alone. Current research about the mechanism of BMP-2 in atherosclerosis and vascular calcification is increasing. In this paper, we will review the research progress about BMP-2-induced arterial calcification in recent years.