c-Myc、SIRT1、acetyl-p53在乳腺癌中的表达及其对预后的影响
| 作者: |
1宋新峰,
1张彦聪,
1张志芹
1 德州学院医药与护理学院，山东 德州 253023 |
| 通讯: |
宋新峰
Email: songxinfeng588@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.05.013 |
| 基金: | 德州市科技计划项目, 2012B12; 2010A62-12 |
摘要
目的：探讨c-Myc、SIRT1及acetyl-p53蛋白在乳腺癌中的表达及其对预后的影响。方法：应用免 疫组织化学方法检测90例乳腺癌和30例乳腺增生症中的c-Myc、SIRT1 (Sirtuin type 1)、acetyl-p53 蛋白表达，结合临床病理资料和随访资料，进行预后分析。结果：c-Myc阳性组乳腺癌患者的 5年无瘤生存率和5年总生存率(分别为59.0%/67.2%)低于c-Myc阴性组(分别为86.2%/86.2%)， SIRT1阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为56.1%/64.9%)低于SIRT1阴 性组(87.9%/87.9%)；acet yl-p53阳性组乳腺癌患者的5年无瘤生存率和5年总生存率(分别为 86.7%/86.7%)高于acetyl-p53阴性组(分别为58.3%/66.7%)，差异均有统计学意义(P<0.05)。结论： c-Myc及SIRT1蛋白高表达的乳腺癌患者预后差，而acetyl-p53蛋白高表达的乳腺癌患者预后好。
关键词：
c-Myc
SIRT1
acetyl-P53
乳腺癌
预后
Expression of c-Myc, SIRT1 and acetyl-p53 in breast carcinoma and prognostic significance
CorrespondingAuthor: SONG Xinfeng Email: songxinfeng588@163.com
DOI: 10.3978/j.issn.2095-6959.2014.05.013
Abstract
Purpose: To study the correlation between c-Myc, Sirtuin type 1 (SIRT1), acetyl-p53 protein and the prognosis of breast carcinoma. Methods: c-Myc, SIRT1 and acetyl-p53 protein of breast carcinoma and breast adenosis were detected by immunohistochemical staining. And combined with follow-up data, statistical analysis was performed to study the prognosis. Results: C-Myc positive breast carcinoma patients, 5-year disease-free survival rate and 5-year overall survival rate (59.0%/59.0%, respectively) is lower than c-Myc negative ones, (86.2%/86.2%, respectively). And SIRT1 positive breast cancer patients, 5-year disease-free suvival rate and 5-year overall survival rate (56.1%/56.1%, respectively) is lower than SIRT1 negative ones, (87.9%/87.9%, respectively). However, Acetyl-p53 positive breast carcinoma patients, 5-year disease-free survival rate and 5-year overall survival rate (86.7%/86.7%, respectively) is higher than the acetyl-p53 negative ones, (58.3%/66.7% respectively). All the difference had statistical significance (P<0.05). Conclusion: Those breast carcinoma patients with c-Myc and SIRT1 protein high expression had a poor prognosis. However, those breast patients with high acetyl-p53 protein expression had a good prognosis.