可溶性人类白细胞抗原G与重度子痫前期的相关性研究
| 作者: |
1王雅萍,
1徐友娣,
1严檬洁
1 南京市第一医院妇产科，南京 210006 |
| 通讯: |
徐友娣
Email: 1217720475@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.05.010 |
摘要
目的：在重度子痫前期患者血浆中的含量水平，探讨sHLA-G在早发型及晚发型重度子痫前期患 者血浆中表达的差异性。方法：选择南京医科大学附属南京医院2013年07月~2014年04月间收 治的6例早发型重度子痫前期患者(早发型组)、18例晚发型重度子痫前期患者(晚发型组)的临床 资料，比较早发型组及晚发型组患者的一般临床情况；应用免疫组织化学染色法(enzyme linked immunosorbent assay，ELISA)，检测6例早发型组，18例晚发型组及32例正常足月妊娠者(正常对 照组)的血清中sHLA-G的表达，并比较三组sHLA-G含量的差异。结果：1)早发型组与晚发型组 的发病孕周，分娩孕周及期待治疗天数差异均有统计学意义(P<0.05)，而年龄差异无统计学意义 (P>0.05)；2)早发型组与晚发型组的收缩压及舒张压差异均有统计学意义(P<0.05)；3)早发型组中 sHLA-G含量均值为4.284±1.932 ng/mL，晚发型组中sHLA-G含量均值为7.036±1.623 ng/mL，正常 孕妇组中sHLA-G含量均值为10.399±3.168 ng/mL。正常对照组sHLA-G含量高于重度子痫前期组 (P<0.01)，且早发型组低于晚发型组(P<0.05)。
关键词：
早发型
晚发型
重度子痫前期
可溶性人类白细胞抗原G
血浆
Study on the correlations between sHLA-G and severe preeclampsia
CorrespondingAuthor: XU Youdi Email: 1217720475@qq.com
DOI: 10.3978/j.issn.2095-6959.2014.05.010
Abstract
Objective: Study soluble human leukocyte antigen G (sHLA G) plasma levels in patients with severe preeclampsia, explore sHLA G-in early-onset and late onset severe preeclampsia patients plasma the differences of the expression. Methods: Selection of the clinical characteristics of six EOSP cases and eighteen LOSP cases in Nanjing first hospital during July 2013 to April 2014. Enzyme linked immunosorbent assay (ELISA) was used to detect sHLA-G level of three groups in the serum. And compare the difference of the results among three groups. Results: 1) There are statistical differences in onset gestational weeks, delivery gestational weeks, days of expectation treatment between early-onset severe preeclampsia (EOSP) and late-onset severe preeclampsia (LOSP) (P<0.05). But no differences were detected in ages and pre-pregnant BMI (P>0.05); 2) there are statistical differences in onset of blood pressure (systolic and diastolic blood pressure) between EOSP and LOSP (P<0.05); 3) the level of sHLA-G was 4.284±1.932, 7.036±1.623 and 10.399±3.168 ng/mL in EOSP group, LOSP group and control group respectively. The sHLA-G level was lower in severe preeclampsia group than that in control group, and also lower in EOSP group than that in LOSP group.