文章摘要

Th细胞在类风湿关节炎发病作用的研究进展

作者: 1王建, 2姜萍
1 山东中医药大学 基础医学院，济南 250355
2 山东中医药大学 内科教研室，济南 250355
通讯: 王建 Email: wangjian8904@163.com
姜萍 Email: ljy6617@163.com
DOI: 10.3978/j.issn.2095-6959.2015.02.022
基金: 山东省高等学校科技计划项目, J12 LK09

摘要

T细胞功能紊乱，尤其是辅助性CD4+T细胞异常活化，在类风湿关节炎(rheumatoid ar thritis，RA) 的发生发展中处于中心环节，CD4+T细胞亚群Th1/Th2细胞及Th17/Treg细胞之间的失衡可能是RA 发病的最直接和最重要的因素。Th细胞相T细胞功能紊乱，尤其是辅助性CD4+T细胞异常活化，在类风湿关节炎(rheumatoid ar thritis，RA) 的发生发展中处于中心环节，CD4+T细胞亚群Th1/Th2细胞及Th17/Treg细胞之间的失衡可能是RA 发病的最直接和最重要的因素。Th细胞相关细胞因子通过作用于多种细胞并相互调节形成一个复 杂的网络，Th1和Th17细胞通过产生炎性细胞因子IFN、TNF-α、IL-2、IL-1、IL-17等造成了滑膜 炎的发生，Th2和Treg细胞通过直接接触或分泌细胞因子IL-4、IL-10等参与抗炎效应。本文旨在阐 述Th细胞及相关细胞因子的促炎和抗炎平衡在RA发生发展中所起的关键作用。
关键词： Th细胞 类风湿关节炎 发病机制 研究进展 文献综述

Research progress of Th cells in the pathogenesis of rheumatoid arthritis

Authors: 1WANG Jian, 2JIANG Ping
1 Shandong University of Traditional Chinese Medicin, School of Basic Medicine, Jinan 250355, China
2 Shandong University of Traditional Chinese Medicin, Department of Internal Medicine Staff room, Jinan 250355, China

CorrespondingAuthor: WANG Jian Email: wangjian8904@163.com

DOI: 10.3978/j.issn.2095-6959.2015.02.022

Abstract

T cell function disorder, especially abnormal activated CD4+T helper cells, plays a central role in the occurrence and development of RA. The imbalance betweenTh1/Th2 cells and Th17/Treg cells in CD4+T cell subsets may be the most direct and important factors in the pathogenesis of RA. Th cell related cytokines by acting on a variety of cells and regulate each other to form a complex network, Th1 and Th17 cells through the production of inflammatory cytokines IFN, TNF-α, IL-2, IL-1, IL-17 etc. caused the happening of synovitis, Th2 and Treg cells by direct contact or the secretion of cytokines IL-4, IL-10 participate in inflammation effect. In this paper, we will briefly review the research progress of Th cells and related cytokines of pro-inflammatory and anti-inflammatory balance in RA.

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