文章摘要

甲胎蛋白和GGT-II联合检测在肝癌患者诊断中的意义

作者: 1李艳明, 2彭敏源, 1简子娟, 3杨旺, 1刘文恩
1 中南大学湘雅医院检验科，长沙 410008
2 中南大学湘雅医院血液科，长沙 410008
3 长沙医学院2008级检验系，长沙 410219
通讯: 刘文恩 Email: liuwenen@gmail.com

摘要

目的：探讨两种肝癌标志物甲胎蛋白(α-fetoprotein，AFP)和γ-谷氨酰转移酶同工酶II(γ-glutamyltransferase isoenzyme II，GGT-II)单独检测和联合检测原发性肝癌(primary hepatocellular carcinoma, PHC)的早期诊断价值。方法：GGT-II检测采用聚丙烯酰胺凝胶电泳法，AFP检测采用电化学发光免疫分析法。分别对33例乙型肝炎患者，30例肝炎后肝硬化患者，44例原发性肝癌患者以及35名健康体检者进行GGT-II和AFP检测，综合分析2项指标对PHC的诊断价值。结果：PHC组的GGT-II和AFP的阳性率均明显高于肝硬化组、肝炎组和健康对照，差异有统计学意义(P<0.01)，联合检测敏感性高于单一检测指标。结论：血清GGT-II及AFP联合检测可提高PHC的诊断灵敏度，提高肝癌的早期检出率。
关键词： 原发性肝癌；甲胎蛋白；γ-谷氨酰转移酶同工酶II；早期诊断

Role of combined detection by AFP and GGT-II in diagnosis of liver cancer

Authors: 1LI Yanming, 2PENG Minyuan, 1JIAN Zijuan, 3YANG Wang, 1LIU Wen'en
1 Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008
2 Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008
3 Department of Clinical Laboratory, Grade 2008 of Changsha Medical University, Changsha 410219, China

CorrespondingAuthor: LIU Wen'en Email: liuwenen@gmail.com

Abstract

Objective: To explore the role of α-fetoprotein (AFP) and γ-glutamyltransferase isoenzyme II (GGT-II) in early diagnosis of primary hepatocellular carcinoma (PHC). Methods: AFP and GGT-II in serum samples from 33 hepatitis B patients, 30 liver cirrhosis patients, 44 primary liver cancer patients and 35 healthy controls were examined by electrochemiluminescence immunoassay and polyacrylamide gel electrophoresis, respectively. Results: The positive rates of AFP and GGT-II in the PHC patients were significantly higher than those in patients with liver cirrhosis, hepatitis B or healthy controls (P<0.01). Combination of two parameters increased the sensitivity compared to single one. Conclusion: Combined detection of serum AFP and GGT-II can improve the sensitivity and early diagnosis rate of PHC.

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