MiRNA调控肿瘤细胞中P-gp表达的研究进展
| 作者: |
1廖焕云,
1唐圣松
1 南华大学药物药理研究所，湖南 衡阳 421001 |
| 通讯: |
唐圣松
Email: tangss111@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.01.014 |
| 基金: | 湖南省高校科技创新平台开放基金, 09K072，12K120 |
摘要
微小RNA (miRNA)是一类高度保守的非编码单链RNA分子，与靶基因mRNA 3'端非编码区结合，抑制mRNA的翻译，促进靶基因降解。而这种调控机制与很多肿瘤细胞中P型糖蛋白(P-glycoprotein，P-gp)的表达有着密切的联系。P-gp是与耐药相关的跨膜蛋白，过表达可导致肿瘤细胞产生多药耐药(multidrug resistance，MDR)。肿瘤MDR是临床化学治疗失败的主要原因，本文就miRNA的生物学特性、P-gp的功能进行综述，并重点介绍其调控肿瘤细胞中P-gp表达和MDR的关系。
关键词：
miRNA；P型糖蛋白；多药耐药；肿瘤
Progress in the role of miRNA in regulation of P-gp expression in tumor cells
CorrespondingAuthor: TANG Shengsong Email: tangss111@163.com
DOI: 10.3978/j.issn.2095-6959.2014.01.014
Abstract
MiRNAs are a class of highly conserved single-stranded non-coding RNAs, which can target mRNA and bind with mRNA 3' UTR to inhibit the translation of mRNA and to promote the degradation of target genes. The regulatory mechanism of miRNA is closely related to P-gp expression in many tumor cells. P-glycoprotein (P-gp) is a transmembrane protein, which can lead to multidrug resistance (MDR) if overexpressed. MDR is a major obstacle to successful chemotherapy in cancer. This review will introduce the biological characteristics of miRNA and the function of P-gp, and the mechanism of miRNA in regulation of P-gp expression will be highlighted.