Objective: To explore the efficacy of photocoagulation of 532 nm-green laser on central serous chorioretinopathy. Methods: Fifty-nine patients with central serous chorioretinopathy were collected from outpatient and inpatient in Department of Ophthalmology in the Sixth People's Hospital of Chengdu from July 2005 to June 2011, and were randomly divided into two groups: a non-drug treatment group (control group, n=24) and a laser treatment group (experimental group, n=35). The period for treatment was 20 weeks, and followed by track of patient for two years. Results: There were highly statistical differences in visual acuity changes, visual acuity changes over time and total efficacy between the two groups (P<0.05), and the symptoms in experimental group was markedly improved. Conclusion: Green laser photocoagulation is a good treatment for central serous chorioretinopathy.