三氧化二砷对原发性肝癌经肝动脉化学治疗栓塞术后血管内皮生长因子表达的影响
| 作者: |
1张海波,
2黄力建,
3朱燕娟,
1李勇,
1白建平,
1潘宗奇,
2孟凡哲
1 广东省中医院 广州中医药大学第二附属医院肿瘤科，广州 510120 2 江门五邑中医院肿瘤科，广东 江门 5290 00 3 广东省中医院 广州中医药大学第二附属医院肿瘤科，广州 510120； |
| 通讯: |
张海波
Email: haibozh@yahoo.com.cn |
| DOI: | 10.3978/j.issn.2095-6959.2013.02.005 |
摘要
目的: 探讨原发性肝癌经肝动脉化学治疗栓塞(transarterial chemoembolization, TACE) 术后给予静脉三氧化二砷治疗对患者血清VEGF 表达水平的影响。目的:连续性选择30 例原发性肝癌TACE 术后的患者, 随机分为治疗组和对照组, 每组15 例病人, 治疗组给予三氧化二砷注射液;对照组给予生理盐水治疗, 比较两组TACE 术前及术后第3, 8, 16 天的血清VEGF 变化。结果:TACE 术后两组患者的血清VEGF 值均动态升高, 术后第3 天和第8 天, 两组血清VEGF 升高的水平基本相同, 差异没有统计学意义(P>0.05)。治疗第16 天时, 治疗组的血清VEGF 水平有明显下降的趋势, 而对照组的血清VEGF 值仍呈直线上升, 两组差异具有统计学意义(P>0.01)。结论:原发性肝癌TACE 术后给予三氧化二砷治疗, 可能降低患者血清VEGF 的表达水平。
关键词：
原发性肝癌；经肝动脉化学治疗栓塞；三氧化二砷；血管内皮生长因子
Effect of arsenic trioxide on vascular endothelial growth factor after transarterial chemoembolization in primary carcinoma of liver
CorrespondingAuthor: ZHANG Haibo Email: haibozh@yahoo.com.cn
DOI: 10.3978/j.issn.2095-6959.2013.02.005
Abstract
Objective: To observe the effect of arsenic trioxide on vascular endothelial growth factor (VEGF) after transarterial chemoembolization in primary carcinoma of liver. Methods: We prospectively studied 30 consecutive primary carcinoma of liver patients after transarterial chemoembolization (TACE), who were randomly divided into a treatment group and a control group. Arsenic trioxide was injected intravenously in patients in the treatment group (n=15), while saline was injected in those in the control group (n=15). The VEGF in serum was tested before TACE and 3, 8, or 16 days after TACE. Results: Compared with that before TACE, the VEGF in serum raised significantly 3 days and 8 days after TACE both in the 2 groups. The VEGF level was not significantly different between the 2 groups (P>0.05). However, the VEGF level decreased significantly 16 days after TACE in the treatment group, while the VEGF level still raised in the control group (P<0.01). Conclusion: Arsenic trioxide may reduce the VEGF level in serum after TACE.