HIF-1表达在肿瘤生长及演进中的作用
| 作者: |
1王丽婷,
1张声
1 福建医科大学附属第一医院病理科，福州350005 |
| 通讯: |
张声
Email: zhgsh@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2013.02.012 |
| 基金: | 福建医科大学第一临床学院学科带头人培养对象专项基金, JXK200724 |
摘要
恶性肿瘤细胞异常增殖的代谢模式，引起氧供应失衡，形成特异性肿瘤缺氧微环境。缺氧通过活化缺氧诱导因子-1(hypoxia induced factor-1，HIF-1)发挥功能，肿瘤细胞中过表达的HIF-1在多种恶性肿瘤生长、演进及放射治疗和化学治疗抵抗中起到关键作用。
关键词：
缺氧诱导因子-1；进展；治疗；肿瘤
Role of HIF-1 expression in invasion and metastasis of malignant tumor
CorrespondingAuthor: ZHANG Sheng Email: zhgsh@126.com
DOI: 10.3978/j.issn.2095-6959.2013.02.012
Abstract
Abnormally accelerated proliferation and metabolism are typical characteristics of malignant tumor cells, which lead to an imbalance between oxygen supply and oxygen consumption in a solid tumour and formation of tumor-specific microenvironment—hypoxia. Hypoxia exerts many effects through activation of a transcription factor—hypoxia-inducible factor 1(HIF-1). Overexpression of HIF-1 contributes to cancer development, progression, resistance to chemo as well as radiation therapy.