胰岛素信号通路与动脉粥样硬化
| 作者: |
1陈灿,
1刘江华,
1祖旭宇,
1文格波
1 南华大学附属第一医院内分泌科,湖南 衡阳421001 |
| 通讯: |
刘江华
Email: jianghua990@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2013.01.011 |
| 基金: | 国家自然科学基金(81170807) |
摘要
动脉粥样硬化(atherosclerosis,AS)性血管病变是导致2型糖尿病患者致残、致死的主要原因之一。最终大部分糖尿病患者死于AS 相关并发症。胰岛素分泌不足和胰岛素抵抗是2型糖尿病的主要病理生理特征。胰岛素受体广泛分布于全身各个器官和组织,胰岛素受体信号通路的激活对维持细胞正常生理功能有重要的作用。
关键词：
胰岛素信号通路
动脉粥样硬化
胰岛素抵抗
Insulin signaling and atherosclerosis
CorrespondingAuthor: LIU Jianghua Email: jianghua990@126.com
DOI: 10.3978/j.issn.2095-6959.2013.01.011
Abstract
Atherosclerotic vascular lesion is one of the most important causes for disability and mortality in diabetic patients. Eventually, the majority of patients with diabetes die from complications related to atherosclerosis. Lack of insulin secretion and insulin resistance are the main pathogenesis for Type 2 diabetes. Insulin receptor is widely expressed in various organs and tissues. Activation of the insulin signaling plays a key role in maintaining the normal physiological function of cells.