TCT筛查中ASC-H的阴道镜检查及组织病理活检的对照研究
| 作者: |
1秦艳,
2彭敏,
3张建兰
1 南方医科大学附属佛山市妇幼保健院 病理科；广东 佛山 528000 2 南方医科大学附属佛山市妇幼保健院 妇产科，广东 佛山 528000 3 南方医科大学附属佛山市妇幼保健院妇产科，广东 佛山 528000 |
| 通讯: |
秦艳
Email: qinyan8595@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2014.02.009 |
摘要
目的：探讨新柏氏液基细胞学检测(Thinprep cytologic test，TCT)在诊断非典型鳞状细胞、不除外高级别鳞状上皮内病变细胞(atypical squamous cells，cannot exclude high-grade squamous intraepithelial lesion，ASC-H)中的诊断意义及临床处理建议。方法：收集2009年1月至2013年3月TCT标本中诊断为ASC-H者118例，对ASC-H患者进行阴道镜检查和阴道镜下活检，最后分析阴道镜检查与阴道镜下组织病理活检结果的关系。结果：118例TCT诊断为ASC-H的患者行阴道镜检查，其中98例行病理活检诊断对照。病理诊断结果为黏膜慢性炎患者10例(10.2 %)，人乳头瘤病毒感染8例(8.2%)，宫颈上皮内瘤样病变I级(cervical intraepithelial neoplasia I，CIN I)17例(17.3%)，CIN II 25例(25.5%), CIN III 28例(28.6%)，浸润性鳞状细胞癌10例(10.2％)。结论：TCT筛查中如诊断为ASC-H，则高度提示宫颈鳞状上皮内瘤变的存在。ASC-H患者应该及时行阴道镜检查及阴道镜下活检以明确诊断，防止漏诊或过度诊断。
关键词：
非典型鳞状细胞；不除外高级别鳞状上皮内病变；阴道镜组织活检；宫颈上皮内瘤变
Comparative study between colposcopy and tissue biopsy in the diagnosis of ASC-H in TCT
CorrespondingAuthor: QIN Yan Email: qinyan8595@sina.com
DOI: 10.3978/j.issn.2095-6959.2014.02.009
Abstract
Objective: To explore the clinical significance and treatment recommendations in the diagnosis of atypical squamous cells with no exclusion of high-grade squamous intraepithelial lesion (ASC-H) in Thinprep cytologic test (TCT). Methods: A total of 118 TCT specimens were collected from the patients diagnosed as ASC-H from January 2009 to March 2013. ASC-H patients were all treated with colposcopy and biopsy under colposcopy. Finally, the relationship between colposcopy and biopsy results was analyzed. Results: Among the 118 patients of ASC-H, the biopsy obtained from 98 patients was served as the control. There were 10 cases of chronic cervicitis (10.2%), 8 cases of human papilloma virus (HPV) infection (8.2%), 17 cases of cervical intraepithelial neoplasia I (CIN I) (17.3%), 25 cases of CIN II (25.5%), 28 cases of CIN III (28.6%), 10 cases of squamous cell carcinoma (10.2%). Conclusion: ASC-H can efficiently distinguish the presence of cervical squamous intraepithelial neoplasia. To prevent misdiagnosis or overdiagnosis, ASC-H patients should be timely carry out colposcopic biopsy under colposcopy.