高尔基体在氧化应激中促凋亡作用的研究进展
| 作者: |
1,2熊炬,
2王佳,
1,2周文胜
2 湖南省老年医院神经疾病研究室，长沙 410016 |
| 通讯: |
王佳
Email: 13875888342@163.com 周文胜 Email: zhouwensheng2004@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.01.015 |
| 基金: | 湖南省医药卫生科研计划课题, B2012-121 湖南省自然科学基金资助, 14JJ2143 |
摘要
高尔基体是细胞内重要的细胞器，除参与细胞内蛋白加工修饰、脂类代谢及囊泡转运等生理活动外，在离子稳态、应激等方面也发挥着重要作用。在氧化应激中高尔基体发生应激反应，功能上出现Ca2+/Mn2+泵活性改变，Ca2+/Mn2+稳态失衡；结构上出现高尔基体碎裂，释放应激性碎裂产物，上述行为将启动高尔基体相关凋亡通路，介导细胞发生凋亡。p115是高尔基体应激相关蛋白，在氧化应激中p115裂解后产生的碎裂片段通过促p53磷酸化而发挥促凋亡作用。
关键词：
氧化应激
高尔基体
p115
凋亡
Advances in studies on apoptosis-inducing effects of golgi apparatus in oxidative stress
CorrespondingAuthor: WANG Jia Email: 13875888342@163.com
DOI: 10.3978/j.issn.2095-6959.2016.01.015
Abstract
As an important organelle inside a cell, golgi apparatus is involved in the physiological activities like the processing and modification of proteins, metabolism of lipids and vesicular transportation. Besides, it plays an important role in the ion homeostasis and stresses. In oxidative stress, the golgi apparatus undergoes the golgi apparatus stress (GA stress). Therefore, the Ca2+/Mn2+ pump activities will alter and GA Ca2+/Mn2+ dyshomeostasis will occur functionally. Structurally, the golgi apparatus will fragment and release the stress-induced fragmentation products. Behavior mentioned above will initiate the relevant apoptotic pathway of the golgi apparatus which mediates its apoptosis. p115 (golgi-vesicular transport protein) is a stress-associated protein; fragments derived from the p115 will exert the apoptosis-inducing effects by inducing the phosphorylation of p53 in oxidative stress.