Kallistatin抗炎作用的研究进展
| 作者: |
1匡枫,
1卿国忠
1 南华大学附属第一医院急诊科，湖南 衡阳 421001 |
| 通讯: |
卿国忠
Email: gzqing9923@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2016.01.014 |
摘要
Kallistatin(KS)是一种激肽释放酶结合蛋白(kallikrein-binding protein)，广泛分布于多种组织及体液中。KS不但具有抑制组织型激肽释放酶的作用，还具有抗炎、抗血管生成、抗肿瘤等多种生物学作用。KS生物学功能与其分子结构中不同的结构域有关。而KS抗炎作用被认为主要与肝素结合结构域有关。KS通过其肝素结合结构域，能竞争性抑制肿瘤坏死因子(tumor necrosis factor α，TNF-α)与它的受体的结合，从而起到影响TNF-α-NF-κB信号通路，发挥抗炎作用。KS也能与Kruppel样因子4(Kruppel-like Factor 4，KLF4)结合，激活内皮型一氧化氮合酶(endothelial nitric oxide synthase，eNOS)，抑制TNF-α活化核因子-κB(nuclear factor-κB，NF-κB)，发挥抗炎作用。但这与肝素结合结构域的机制不同。不同的机制可能为抗炎治疗提供新的思路，本文将就Kallistatin抗炎作用的相关研究进展进行阐述。
关键词：
Kallistain
抗炎
结构域
The research progress of the anti-inflammatory effect of kallistatin
CorrespondingAuthor: QING Guozhong Email: gzqing9923@163.com
DOI: 10.3978/j.issn.2095-6959.2016.01.014
Abstract
Kallistatin (KS) is a kallikrein-binding protein, which is widely distributed in multiple tissues and body fluids. KS not only has inhibitory effect to tissue kallikrein, but also has anti-inflammatory, anti-angiogenesis, anti-tumor and other biologic functions. The biologic function of KS is related to its molecular structure, which has different structural domains. The anti-inflammatory effect of KS is considered to be mainly related to the heparin-binding domain. Through this domain, KS can competitively inhibit tumor necrosis factor (TNF-α) combined with its receptors, and influence TNF-α-NF-κB signal pathway, contribute to anti-inflammatory effect. KS can also combine with Kruppel-like Factor 4 (KLF4), activating endothelial nitric oxide synthase (eNOS), as well as suppress TNF-α-induced nuclear factor-κB (NF-κB) activation, contribute to anti-inflammatory effect. But this mechanism is different from the mechanism of heparin-binding domain. Different mechanisms may provide a new idea for the anti-inflammatory treatment. This review focuses on the latest research progress in the anti-inflammatory effect of KS.