Objective: To explore the application of comprehensive nursing measures in reducing the incidence of adverse reaction of CT contrast enhancement scanning contrast agent. Methods: 300 cases in our hospital from December 2014 to December 2015 were randomly divided into experimental group and control group. The patients of control group underwent conventional CT enhanced scanning after CT contrast enhancement scanning, while the patients of the experimental group underwent conventional CT scanning, as well as comprehensive nursing measures, including preventive care, inspection and other aspects of care from the health education, psychological nursing, optimizing selection of blood vessels. The changes of vital signs, the occurrence of adverse reactions, the degree of satisfaction, anxiety and depression happened to two groups of patients were measured in the process. Results: The patients in the experimental group had a n abnormal rate of blood pressure lower than that in control group after the comprehensive nursing measures (P<0.05), and the incidence of anxiety and depression in the experimental group was lower than that of the control group (P<0.05). The satisfaction of the experimental group about nursing work is higher than that in the control group (P<0.05). The adverse reaction incidence of the experimental group were lower than that in the control group (P<0.05). Conclusion: The comprehensive nursing measures can reduce the adverse reaction, improve the bad mood, and improve the satisfaction of nursing work in patients with CT contrast enhancement scanning.