去泛素化酶影响低氧诱导因子-1α泛素化过程的研究进展
| 作者: |
1孙微,
1,2师永红
1 内蒙古医科大学，呼和浩特 010110 2 内蒙古医科大学附属医院病理科，呼和浩特 010050 |
| 通讯: |
孙微
Email: sw_rupon@163.com 师永红 Email: 13514815271@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.11.032 |
| 基金: | 国家自然科学基金, 81360395 |
摘要
低氧诱导因子-1α(hypoxia-inducible factor-1α，HIF-1α)是一种具有氧依赖性的核转录调控因子。在缺氧条件下HIF-1α大量聚集于细胞浆，继而转入细胞核促进靶基因转录表达，增强肿瘤的增殖、侵袭和转移能力；常氧条件下，HIF-1α的合成与降解水平保持相对平衡，其降解主要通过泛素-蛋白酶体途径实现。大量研究已经证实，去泛素化酶不仅可以有效逆转HIF-1α的泛素化-蛋白酶体降解过程，也可以通过各种途径促进肿瘤的发生发展，本文就去泛素化酶影响HIF-1α泛素化过程的作用机制作一综述。
关键词：
低氧诱导因子-1α
泛素化
去泛素化酶
去泛素化
Research progression in ubiquitination enzymes in the ubiquitination of hypoxia-inducible factor-1α
CorrespondingAuthor: SUN Wei Email: sw_rupon@163.com
DOI: 10.3978/j.issn.2095-6959.2015.11.032
Abstract
Hypoxia-inducible factor -1α (HIF-1α) is a kind of oxygen-dependent nuclear transcriptional factors. Under hypoxic conditions, HIF-1α accumulates in cytoplasm and then transfers into nucleus to promote transcription and expression of its target genes, enhancing proliferation, invasion and metastasis of tumors; while under normoxic conditions, the synthesis and degradation of HIF-1α protein remain relatively balanced. HIF-1α is mainly degraded via the ubiquitin-proteasome pathway. Numerous studies showed that ubiquitination enzymes not only effectively reverses the ubiquitin-proteasome degradation process of HIF-1α, but also promote the tumor progress through various ways. This review focus on the mechanisms of deubiquitination enzymes affecting ubiquitination of HIF-1α.