Objective: To probe into the diagnostic application value of endometrial carcinoma and precancerous lesions by endometrial collector, liquid based cytology, cell module technology. Methods: A total of 305 out-patients in our hospital need to detect endometrial lesions. Using endometrial collector to get the endometrial cells, at the same time carry out diagnostic curettage. Then use liquid based cytology, cell module to make, and compared with histological results diagnostic curettage. Results: the sensitivity and specificity of the diagnosis of endometrial atypical hyperplasia were 55%, 82.6% and 37.6% respectively. The sensitivity of the diagnosis of endometrial cancer was 36.4%, the specificity was 99.7%, and the Youden index was 36.1%. Compared with the gold standard, the sensitivity of the diagnosis of endometrial atypical hyperplasia was 70%, specificity was 90.2%, Youden index was 60.2%, the sensitivity of diagnosis of endometrial cancer was 54.55%, specificity was 98.63% and Youden index was 53.2%. Conclusion: The use of endometrial cell collection, liquid based cytology, cell module production, can be used to screen for the symptoms of people and high-risk groups of endometrial lesions, but in the process of cytological examination of diagnostic techniques and sampling tools are also expected to improve.