RGC-32在结肠癌组织中的表达及临床意义
| 作者: |
1汪再炎,
1丁百静
1 安徽省芜湖市第二人民医院消化内科，安徽 芜湖 241000 |
| 通讯: |
汪再炎
Email: 605206566@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.11.021 |
摘要
目的：探讨RGC-32(response gene to complement 32)在结肠癌组织中的表达及其与临床病理特征的关系。方法：选取2012年1月至2015年3月期间芜湖市第二人民医院收治的45例结肠癌患者及20例正常患者行结肠镜活检或结肠癌根治术的标本，采用免疫组织化学SP法检测RGC-32在结肠癌组织中的表达，分析RGC-32表达与结肠癌临床病理特征的关系。结果：RGC-32在结肠癌组织中的表达明显高于正常结肠黏膜组织(84.4% vs. 15%，P<0.05)；结肠癌组织中RGC-32高表达与肿瘤大小、分化程度、TNM分期及淋巴结转移等呈正相关(P<0.05)，与患者年龄、性别无关(P>0.05)。结论：RGC-32在结肠癌高表达，并参与结肠癌的发生、发展。
关键词：
结肠癌
RGC-32
免疫组织化学
Detection of RGC-32 expression in colon cancer and its significance
CorrespondingAuthor: WANG Zaiyan Email: 605206566@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.11.021
Abstract
Objective: To detect the expression of response gene to complement 32 (RGC-32) in colon cancer and its relation with clinicopathological features. Methods: RGC-32 expression was tested with immunohistochemistry in 45 cases of colon cancer patients’ and 20 normal patients’ specimen, which were got by colonoscopy biopsy or colon cancer surgery. The patients were treated in the Wuhu No.2 People’s Hospital from Jan 2012 to Mar 2015. The correlation between RGC-32 expression and clinicopathological features of colon cancer were analyzed. Results: The expression of RGC-32 in colon cancer was significantly higher than that in normal colonic mucosa tissue(84.4% vs. 15%, P<0.05); The over-expression of RGC-32 in colon cancer was positively related to the tumor size, differentiation degree, TNM staging and lymph node metastasis (P<0.05), but not related to age and sex (P>0.05). Conclusion: RGC-32 is over-expressed in colon cancer and related to development of colon cancer.