Objective: To investigate fungal nose-sinusitis associated risk factors and clinical manifestations. Methods: Selected from February 2009 to January 2015 in our hospital fungal nose-sinusitis 89 patients (observation group), simultaneously selected 101 cases of chronic nasal sinusitis patients (control group), collected the clinical data of two groups of patients, used non-conditional Logistic regression to analyze fungal nose-sinusitis related risk factors. Results: The average age of the patients in the observation group was (47.04±11.43) years, significantly higher than the control group, the difference was statistically significant (P<0.05); Observation group and the control group gender and disease duration difference were statistically significant (P<0.05), the observation group the proportion of women, duration ≤3 years the proportion were significantly higher than those of the control group; Observer group snivel with blood and facial discomfort rates were 31.46% and 50.56%, significantly higher than control group (P<0.05); Observer group nasal congestion, hyposmia and polypoid rates were 41.57%, 15.73% and 19.10% was significantly lower than the control group (P<0.05); Observation group single sinus disease, unilateral disease, dense shadow, calcification and bone hyperplasia imaging performance ratio were 73.03%, 82.02%, 76.04%, 29.21% and 19.10%, significantly higher than the control group (P<0.05); Non-conditional Logistic regression analysis showed: age, snivel with blood and dense shadow, calcification, single sinus disease were the risk factors of fungal nose-sinusitis. Conclusion: Fungal nose-sinusitis clinical features and CT imaging features has high specificity, precautions should be taken against the relevant risk factors.