2014年长沙地区16 395例儿童维生素D水平分析
| 作者: |
1姚碧容,
2成婧,
2钟昊,
2龚强
1 湖南省妇幼保健院检验科，长沙 410005 2 湖南出入境检验检疫局，长沙 410004 |
| 通讯: |
姚碧容
Email: 39235213@qq.com 成婧 Email: analytic_ching@163.com 钟昊 Email: Zhonghao@hnciq.gov.cn 龚强 Email: gongqiang6934@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.10.016 |
摘要
目的：比较分析长沙地区部分儿童维生素D水平，为临床合理补充维生素D、改善儿童户外活动习惯以促进维生素D的合成提供科学依据。方法：收集我院2014年长沙地区16 395例0~12岁健康体检儿童血清标本，通过酶联免疫吸附试验(ELISA)方法检测血清25-羟基维生素D[25-hydroxyvitaminD，25-(OH)D]，采用单因素方差分析等统计学方法全面分析了不同年龄、性别以及一年中不同月份维生素D水平差异。结果：0~12岁儿童血清25-(OH)D平均水平为(59.2±24.5) nmol/L，远低于充足水平；<1月婴儿组与1~2月婴儿组间差异无统计学意义、学龄前组组与学龄组间差异无统计学意义(P>0.05)，其他各组间差异均有统计学意义(P<0.05)；不同性别间血清25-(OH)D水平差异无统计学意义(P>0.05)；一年中10月份血清25-(OH)D水平最高，平均值为(68.5±24.8) nmol/L，1~10月水平呈逐步上升趋势，11月、12月又逐步下降。结论：长沙地区儿童需要增加户外活动时间，延长维生素D补充摄入时间，用以改善维生素D缺乏与不足的普遍现象。
关键词：
维生素D
25-羟基维生素D
儿童
长沙
Analysis of the vitamin D level among 16 395 children in Changsha area in 2014
CorrespondingAuthor: YAO Birong Email: 39235213@qq.com
DOI: 10.3978/j.issn.2095-6959.2015.10.016
Abstract
Objective: Analyzing the vitamin D level of children in Changsha area, to provide theoretical basis for clinical vitamin D supplement and improvement of vitamin D synthesis through outdoor activities. Methods: The serum samples of 0~12 years old healthy children of Changsha area in 2014 were collected. Serum 25-hydroxyvitamin D [25-(OH)D] concentrations were determined by ELISA kits. The differences of serum 25-(OH)D from different ages, gender, and months among a year were analyzed by One-Way ANOVA. Results: The average 25-(OH)D level of 0~12 years old healthy children was (59.2±24.5) nmol/L, far below the adequacy standards of >75 nmol/L. There was no statistical difference between <1 month old infant group and 1~2 months old infant group (P>0.05). There was no statistical difference between preschool age group and school age group (P>0.05). There was statistical difference between other groups (P<0.05). In 2014, the highest 25-(OH)D level appeared in October, was (68.5±24.8) nmol/L. The value of serum 25-(OH)D gradually increased from January to October, and then went down in November and December. Conclusion: Children in Changsha area needed to have more outdoor activities, and extend vitamin D supplement intake time, so that ameliorate the common phenomenon of vitamin D deficiency.