Objective: To investigate the effect of stretching combined with resistance exercise on muscle strength and cardiopulmonary function in elderly patients with stroke. Methods: A total of 62 patients in the Geriatric Ward of the Affiliated Hospital of Jiangnan University from January to August 2022 were selected as research subjects by the random sampling method, and 5 patients withdrew from the study. The remaining 57 patients were randomly divided into an intervention group (n=28) and a control group (n=29). Both groups were given the same nursing intervention, and the intervention group was given exercise intervention at the same time (stretching combined with resistance exercise three times a week for 6 months). The changes of muscle strength, repeated sitting times in 30 s, maximal oxygen uptake (VO2max), and 6-minute walk test (6MWT) were compared between the 2 groups before the intervention, 3, and 6 months after the intervention. Results: After the intervention, the muscle strength and 30 s repeated sitting times in the intervention group were higher than those in the control group at 3 and 6 months (both P<0.05). The VO₂max and 6MWT in the intervention group were higher than those in the control group at 3 and 6 months after the intervention (both P<0.05), and the differences became increased with time. Conclusion: Stretching combined with resistance exercise can improve muscle strength and cardiopulmonary function in elderly patients with stroke, and the longer the intervention, the better the effect.