Objective: To explore the early diagnosis and management of acute fatty liver of pregnancy (AFLP) so as to improve maternal and fetal survival. Methods: The clinical findings and outcomes of pregnancy were retrospectively analyzed in 15 patients with AFLP in this hospital from January 2011 to January 2015. Results: A total of 15 AFLP manifested in the third trimester, 12 of whom were nulliparas and 3 of whom were multiparas; 13 of whom were singleton pregnancy and 2 of whom were twin pregnancy. There were total 17 fetuses, 12 of whom were males and 5 of whom were females. There were 7 patients with hypertension, 9 with lower blood glucose levels, and 13 with symptoms, including nausea, vomiting and anorexia. The duration from admission to fetal delivery was 0.5~21.5 hours. All patients preserved their uteri, with 14 patients ending the pregnancy with cesarean section and 1 with vaginal delivery. Two patients were complicated with postpartum hemorrhage. There was no maternal death. Fourteen newborns were normal, 1 was asphyxia and 3 were fetal deaths. Conclusion: The key to improving the prognosis of both mothers and fetuses is to make early diagnosis and to end the pregnancy timely. Multimodality therapy with the help of multiple departments and the artificial liver support system timely are efficient in reducing the maternal mortality.