Objective: To explore the effect of continuous nursing under the medical alliance mode on self-management ability and blood glucose control in patients with type 2 diabetes (T2DM). Methods: A total of 100 patients with T2DM admitted to the endocrinology department of Second People’s Hospital of Fuyang City from October 2020 to September 2021 were selected as research subjects. According to the random number table method, the patients were divided into a control group and an observation group, with 50 cases in each group. The control group received routine continuous nursing, and the observation group received continuous nursing under the medical alliance mode. After 1 year of intervention, the self-management ability [Improved Summary of Diabetes Self-Care Activities Scale (SDSCA)], blood glucose related biochemical indexes [fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), and postprandial 2 h blood glucose (2hPG)], and quality of life [Diabetes Specific Quality of Life (DSQL)] were compared between the 2 groups. Results: After the intervention, the total scores of SDSCA scale and scores of each subscale in the 2 groups were significantly increased (all P<0.05), those in the observation group were higher than those in the control group (all P<0.05), and the difference of SDSCA scores before and after the intervention in the observation group was greater than those in the control group (all P<0.05). FPG, HbAlc, and 2hPG in both groups decreased (all P<0.05), those in the observation group were lower than those in the control group (all P<0.05), and the difference of FPG, HbAlc, and 2hPG before and after the intervention in the observation group was greater than those in the control group (all P<0.05). The total score and each subscale score of the DSQL scale in the 2 groups were significantly decreased (all P<0.05), the observation group was lower (all P<0.05), and the difference of DSQL scale total score and each subscale score before and after the intervention in the observation group was greater than those in the control group (all P<0.05). Conclusion: The implementation of continuous nursing under the medical alliance mode can significantly improve the self-management ability in patients with T2DM, which is conducive to the control of blood glucose and thus improve the quality of life of patients.