文章摘要

生物钟和肝代谢及肝癌发生的研究进展

作者: 1,2侯正辉, 3张卉, 1胡龙泉, 1,4袁鹏
1 空军军医大学第二附属医院核医学科，西安 710038
2 空军军医大学基础医学院学员二大队六队，西安 710032
3 西安市儿童医院超声诊断科，西安 710002
4 空军军医大学第二附属医院介入疼痛科，西安 710038
通讯: 袁鹏 Email: yuanpeng834700@126.com
DOI: 10.3978/j.issn.2095-6959.2022.11.035
基金: 中国博士后科学基金(2020T130787，2019M663984)；陕西省自然科学基础研究计划(2022JQ-930)；空军军医大学人才扶持项目—“雏鹰计划”(2020cyjhyp)；空军军医大学第二附属医院国家自然科学基金助推项目计划(2021ZTXM-002)。

摘要

生物钟是生物体内具有自我调节功能、与昼夜交替同步的一种生理机制。生物钟通过内部生物钟基因控制哺乳动物节律性的生理活动进程。生物钟基因紊乱与肝癌的发生密切相关。理解生物钟基因在肝代谢和肝癌发生中的作用，有可能为肝癌的诊断、治疗及预后提供新的研究方向和思路。
关键词： 生物钟；肝代谢；肝癌发生

Advances in the circadian clock and liver metabolism and hepatocarcinogenesis

Authors: 1,2HOU Zhenhui, 3ZHANG Hui, 1HU Longquan, 1,4YUAN Peng
1 Department of Nuclear Medicine, Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China
2 Team 6, Cadets Group 2, Basic Medical College, Air Force Medical University, Xi’an 710032, China
3 Department of Ultrasound, Xi'an Children’s Hospital, Xi’an 710002, China
4 Department of Intervention and Pain, Second Affiliated Hospital of Air Force Medical University, Xi’an 710038, China

CorrespondingAuthor: YUAN Peng Email: yuanpeng834700@126.com

DOI: 10.3978/j.issn.2095-6959.2022.11.035

Foundation: This work was supported by China Postdoctoral Science Foundation (2020T130787; 2019M663984), Shaanxi Provincial Natural Science Basic Research Program (2022JQ-930), Air Force Medical University Talent Support LingYun Project-Eagle Program (2020cyjhyp), and The Natural Science Foundation-Boosting Project Plan of the Second Affiliated Hospital of Air Force Medical University (2021ZTXM-002), China.

Abstract

Circadian clock is a physiological mechanism of the organism that has the function of self-regulatory and synchronizes with day-and-night alteration. Circadian clock is also a process of physiological activity that controls the rhythmicity of mammals through internal circadian clock genes. Circadian clock gene disorder is closely related the tumorigenesis of liver cancer. Understanding the role of circadian clock genes in liver metabolism and hepatocarcinogenesis will help to provide new research directions and ideas in the diagnosis, treatment and prognosis of liver cancer.

Keywords： circadian clock; liver metabolism; hepatocarcinogenesis

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