Objective: To analyze the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) combined with virtual touch tissue imaging quantification (VTIQ) for sentinel lymph node (SLN) in breast cancer. Methods: A total of 104 breast cancer patients (104 SLNs) admitted to our hospital from April 2018 to February 2021 were selected. Preoperative CEUS and shear wave elastography were performed to analyze SLN metastasis. With pathological results as the gold standard, the efficacy of CEUS, SWV and combined diagnosis in predicting SLN metastasis in breast cancer was analyzed. Results: Among the 104 SLNS confirmed by postoperative pathology, 34 were metastatic (metastatic SLN group) and 70 were non metastatic (non-metastatic SLN group). There was statistically significant difference in the proportion of SLN typing by CEUS between the metastatic group and the non-metastatic SNL group (P<0.05). In addition, compared with SWVmean of VTIQ, the difference was also statistically significant (P<0.05); type I under CEUS was classified as non-metastatic SNL (−), and type II and above were classified as metastatic SNL (+). Compared with the gold standard (postoperative pathological examination results), the sensitivity was 88.2% (30/34) and the specificity was 71.4% (50/70); the ROC curve of SMVmean for the diagnosis of metastatic SNL was drawn. The area under the curve was 0.838, the best cut-off value was 2.62 m/s, and the sensitivity and specificity were 76.5% and 82.8%, respectively. The sensitivity and specificity of CEUS and VTIQ in the diagnosis of metastatic SNL were 94.1% (32/34) and 91.4% (64/70). Conclusion: CEUS combined with VTIQ has high diagnostic efficiency for SLN metastasis of breast cancer, and improves the diagnostic accuracy.