文章摘要

DAXX翻译后修饰的研究进展

作者: 1张燕, 1李天平, 1,2庹勤慧
1 南华大学药物药理研究所，湖南 衡阳 421001
2 湖南中医药大学，长沙 410208
通讯: 庹勤慧 Email: qhtuo@aliyun.com
DOI: 10.3978/j.issn.2095-6959.2014.06.032
基金: 国家自然科学基金项目, 30971170，30770868，30971267 湖南省高校创新平台开发基金项目, 12K096 湖 南省杰出青年基金, 14JJ1024

摘要

Fas死亡结构域相关蛋白(Fas death domain-associated protein) DAXX是一种高度保守的核蛋白，广泛 分布于核质、核仁、胞浆、异染色质和早幼粒细胞白血病蛋白核体(PML-NBs)等亚细胞区域，在 细胞凋亡和转录调控中发挥重要作用。DAXX功能的调控涉及一系列的翻译后修饰，包括泛素化修 饰、类泛素样蛋白修饰、磷酸化修饰，通过修饰，可引起DAXX在各亚细胞区域间的转位，也可引 起DAXX参与的生理功能的改变。本文对DAXX此方面的研究进展做一综述。
关键词： 死亡结构域相关蛋白 泛素化修饰 类泛素样蛋白修饰 磷酸化修饰

Post-translational modification of DAXX

Authors: 1ZHANG Yan, 1LI Tianping, 1,2TUO Qinhui
1 Institute of Pharmacy and Pharmacology, University of South China, Hengyang Hunan 421001
2 Hunan University of Chinese Medicine, Changsha 410208, China

CorrespondingAuthor: TUO Qinhui Email: qhtuo@aliyun.com

DOI: 10.3978/j.issn.2095-6959.2014.06.032

Abstract

Fas death domain-associated protein DAXX, a highly conserved and multifunctional protein that is widely distributed in the nucleoplasm, nucleolus, cytoplasm, heterochromatin, promyelocytic leukemia nuclear bodies (PML-NBs) and other subcellular localization, plays an important role in the regulation of transcription and apoptosis. This regulation of DAXX involves a series of post-translational modifications, including ubiquitination, ubiquitin-like protein modification and phosphorylation, through modification, causing the translocation of DAXX among subcellular regions and the changes of physiological functions. This review will provide a summary for post-translational modifications of DAXX.

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