文章摘要

血清炎症因子及甲状腺功能与产后抑郁症患者负性情绪变化的相关性

作者: 1沈红, 1杨冬梅, 1胡敏玉, 1徐晓茜
1 江阴市中医院妇产科，江苏 江阴 214400
通讯: 徐晓茜 Email: syn04200531@163.com
DOI: 10.3978/j.issn.2095-6959.2022.10.020

摘要

目的：探讨血清炎症因子及甲状腺功能与产后抑郁症患者负性情绪变化的相关性。方法：选择2020年2月至2022年2月江阴市中医院产科病房收治的住院产妇，于产后7 d使用爱丁堡产后抑郁量表(Edinburgh Postpartum Depression Scale，EPDS)进行评估，将符合诊断标准、纳入排除标准者纳入产后抑郁症组，同期来院复查的无产后抑郁的产妇120例作为对照组。采用酶联免疫吸附法检测两组血清超敏C反应蛋白(high-sensitivity C-reactive protein，hs-CRP)、白细胞介素-1β(interleukin-1β，IL-1β)、白细胞介素-2(interleukin-2，IL-2)、白细胞介素-6(interleukin-6，IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)水平；采用化学发光分析仪检测两组血清三碘甲状腺原氨酸(triiodothyronine，T3)、四碘甲状腺原氨酸(tetraiodothyronine，T4)、血清游离三碘甲状腺原氨酸(free triiodothyronine，FT3)、血清游离甲状腺素(free thyroxine，FT4)、促甲状腺激素(thyroid-stimulating hormone，TSH)水平；采用汉密尔顿焦虑量表(Hamilton Anxiety Scale，HAMA)、汉密尔顿抑郁量表(Hamilton Depression Rating Scale，HAMD)评价两组负性情绪；采用Pearson相关性分析对血清炎症因子水平、甲状腺功能指标与产后抑郁症患者负性情绪变化的进行分析。结果：产后抑郁症组hs-CRP、IL-1β、IL-2、IL-6、TNF-α水平均高于对照组(P<0.05)；产后抑郁症组T3、T4、TSH水平均低于对照组(均P<0.05)；产后抑郁症组HAMA、HAMD评分高于对照组(P<0.05)；产后抑郁症患者负性情绪与血清hs-CRP、IL-2、IL-6、TNF-α水平呈正相关，与TSH指标呈负相关(P<0.05)。结论：产后抑郁症与产妇体内促甲状腺激素水平及血清炎症因子水平相关。
关键词： 血清炎症因子水平；甲状腺功能；产后抑郁症；负性情绪；相关性

Correlation of serum inflammatory factor levels and thyroid function with negative emotional changes in patients with postpartum depression

Authors: 1SHEN Hong, 1YANG Dongmei, 1HU Minyu, 1XU Xiaoqian
1 Department of Obstetrics and Gynecology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Jiangsu 214400, China

CorrespondingAuthor: XU Xiaoqian Email: syn04200531@163.com

DOI: 10.3978/j.issn.2095-6959.2022.10.020

Abstract

Objective: To investigate the correlation of serum inflammatory factors and thyroid function with negative emotional changes in patients with postpartum depression. Methods: From February 2020 to February 2022, pregnant women admitted to the obstetrics ward of Jiangyin Hospital of Traditional Chinese Medicine were selected and evaluated using the Edinburgh Postpartum Depression Scale (EPDS) 7 d after the delivery. Those who met the diagnostic criteria and were included in the exclusion criteria were included in a postpartum depression group. Another 120 cases of pregnant women without postpartum depression who came to the hospital for reexamination during the same period were selected as a control group. Enzyme-linked immunosorbent assay was used to detect serum high-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels in the 2 groups; chemiluminescence analyzer was used to detect serum triiodothyronine (T3), tetraiodothyronine (T4), free triiodothyronine (FT3), serum free thyroxine (FT4), and thyroid-stimulating hormone (TSH); negative emotions were evaluated by Hamilton Anxiety Scale (HAMA) and Hamilton Depression Rating Scale (HAMD) in the 2 groups. The correlation of inflammatory factor levels, thyroid function indexes and negative mood changes in patients with postpartum depression was analyzed. Results: The levels of hs-CRP, IL-1β, IL-2, IL-6, and TNF-α in the postpartum depression group were higher than those in the control group (P<0.05); the levels of T3, T4, and TSH in the postpartum depression group were lower than those in the control group (all P<0.05); HAMA and HAMD scores in the postpartum depression group were higher than those in the control group (P<0.05); negative emotions in postpartum depression patients were significantly positively correlated with serum hs-CRP, IL-2, IL-6, and TNF-α levels. There was a significant negative correlation with the TSH index (P<0.05). Conclusion: Postpartum depression is associated with maternal thyroid-stimulating hormone levels and serum inflammatory factor levels.

Keywords： serum inflammatory factor levels; thyroid function; postpartum depression; negative emotion; correlation

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