Neuropeptide Y (NPY) is one of the most abundant neuropeptide in the human body, based on introduction of NPY biological characteristics and receptors, this paper describes the releasing active NPY binding to angiogenesis-related receptors was concentration-dependent bimodality directly stimulating angiogenesis, and by up-regulating the expression of angiogenesis related receptors, inducting the expression of other angiogenic growth factors and decreasing the expression of angiogenesis inhibiting factors, mobilizating mesenchymal stem cells and endothelial progenitor cells and other ways to promote angiogenesis, it provides basis for clinical prevention and treatment of certain diseases.