文章摘要

LASS2/TMSG-1 基因与肿瘤转移关系的研究进展

作者: 1左华楚, 2李秀霞, 2徐晓艳
1 内蒙古医科大学 研究生院；第一附属医院病理科；基础医学院病理学教研室，呼和浩特 010059
2 内蒙古医科大学 第一附属医院病理科；基础医学院病理学教研室，呼和浩特 010059
通讯: 李秀霞 Email: NYLXX@sina.com
基金: 国家自然科学基金(81201854)

摘要

人源性长寿保障基因2 (homo sapiens longevity assurance homologue 2，LASS2)是一个与酵母长寿保障基因1(longevity assurance gene1，LAG1)高度同源的人类基因，又被称为肿瘤转移抑制相关基因1 (tumor metastasis suppressor gene-1，TMSG-1)。目前研究发现LASS2/TMSG-1与神经酰胺合成密切相关，同时其与V-ATPase质子泵的相互作用被认为是抑制肿瘤转移的机制之一， 多种肿瘤的转移都与此基因的表达相关。
关键词： LASS2/TMSG-1；神经酰胺；V-ATPase质子泵；肿瘤转移

LASS2/TMSG-1 gene and tumor metastasis

Authors: 1ZUO Huachu, 2LI Xiuxia, 2XU Xiaoyan
1 Graduate School; Department of Pathology, First Affiliated Hospital; Department of Pathology Teaching and Research, Basic Medical College, Inner Mongolia Medical University, Hohehot 010059, China
2 First Affiliated Hospital; Department of Pathology Teaching and Research, Basic Medical College, Inner Mongolia Medical University, Hohehot 010059, China

CorrespondingAuthor: LI Xiuxia Email: NYLXX@sina.com

Abstract

The homo sapiens longevity assurance homologue 2 (LASS2) has a highly homologous with yeast longevity assurance gene 1 (LAG1), which was also known as tumor metastasis suppressor gene 1 (TMSG1). The LASS2 / TMSG-1 is closely related to the ceramide synthesis and its interaction with V-ATPase proton pump is considered to be one of the mechanisms for tumor metastasis. A variety of tumor metastasis is associated with the expression of this gene.

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