脂肪细胞三酰甘油分解代谢相关调节的研究进展
| 作者: |
1黄文钰,
1李向平
1 中南大学湘雅二医院心内科，长沙 410011 |
| 通讯: |
李向平
Email: lixp@medmail.com.cn |
| DOI: | 10.3978/j.issn.2095-6959.2013.03.010 |
摘要
脂肪组织是体内重要的能量储存和供应站，脂肪细胞中的三酰甘油分解代谢紊乱与肥胖等代谢疾病密切相关。在多种脂肪分解途径中，有许多机制尚未明确。已知激素敏感性脂肪酶、脂肪三酰甘油脂肪酶是重要的脂肪细胞三酰甘油水解酶，围脂滴蛋白是脂肪分解的重要调节因子。本综述将着重介绍脂肪细胞三酰甘油分解代谢的主要调节通路和上述酶及蛋白作用机制方面的研究进展。
关键词：
脂肪细胞；三酰甘油；激素敏感性脂肪酶；脂肪三酰甘油脂肪酶；围脂滴蛋白
Research progress in regulation of triglyceride hydrolysis in adipocytes
CorrespondingAuthor: LI Xiangping Email: lixp@medmail.com.cn
DOI: 10.3978/j.issn.2095-6959.2013.03.010
Abstract
Adipose tissue is an important station for energy storage and service in the body. The dysregulation of triglyceride hydrolysis is related to obesity and other lipid metabolism disorders. Hormone-sensitive lipase (HSL) and adipose triacylglycerol lipase(ATGL) are major enzymes for triglyceride hydrolysis. Perilipin is an important regulatory factor for lipolysis. This review summarized advance in research on the main regulatory pathway for triglyceride hydrolysis and the roles of HSL, ATGL, and perilipin in triglyceride hydrolysis in adipocytes.