443例恶性淋巴瘤临床病理特征分析
| 作者: |
1吴永芳,
1许春伟,
1韩鸿雁,
1王海艳,
1邵云,
1张博,
1李晓兵,
2苏航,
2张伟京
1 军事医学科学院附属医院病理科， 北京 100071 2 军事医学科学院附属医院淋巴头颈肿瘤科， 北京 100071 |
| 通讯: |
许春伟
Email: xuchunweibbb@163.com 张博 Email: zenwo@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2015.07.013 |
摘要
目的：根据WHO(2008版)造血和淋巴肿瘤分类标准，探讨军事医学科学院附属医院恶性淋巴瘤的病理类型及分布特点。方法：收集2010年11月1日至2015年3月31日病理诊断443例恶性淋巴瘤，复习其临床资料、HE切片及免疫组织化学切片。按WHO(2008版)分类标准进行病理诊断及分类。结果：443例恶性淋巴瘤中霍奇金淋巴瘤11.06%(49/443)，非霍奇金淋巴瘤(non-Hodgkin’slymphoma，NHL)88.94%(394/443)。非霍奇金淋巴瘤中B细胞性淋巴瘤66.37%(294/443)，T细胞性淋巴瘤22.35%(99/443)。非霍奇金淋巴瘤中，发病构成比居前5位分别为弥漫性大B细胞淋巴瘤41.53%(184/443)、滤泡性淋巴瘤11.06%(49/443)，外周T细胞淋巴瘤5.64%(25/443)，T淋巴母细胞白血病/淋巴瘤5.19%(23/443)、黏膜相关淋巴组织结外边缘区淋巴瘤4.74%(21/443)。HL中以结节硬化型经典型霍奇金淋巴瘤为多(4.51%，20/443)。恶性淋巴瘤患者中，男女比例为1.58∶1，中位年龄57岁(7~94岁)。霍奇金淋巴瘤和非霍奇金淋巴瘤起病部位均以颈部淋巴结为多。结论：443例淋巴瘤中，非霍奇金淋巴瘤发病远多于霍奇金淋巴瘤，非霍奇金淋巴瘤中以弥漫大B细胞淋巴瘤多见，霍奇金淋巴瘤中以结节硬化性霍奇金淋巴瘤多见。大部分淋巴瘤类型以男性发病为多，起病部位以颈部淋巴结为多。
关键词：
淋巴瘤
恶性
临床病理分析
Clinical and pathological analysis of 443 cases with malignant lymphoma
CorrespondingAuthor: XU Chunwei Email: xuchunweibbb@163.com
DOI: 10.3978/j.issn.2095-6959.2015.07.013
Abstract
Objective: To explore clinical and pathological type and distribution among malignant lymphoma in Affiliated Hospital of Academy of Military Medical Sciences, according to the World Health Organization criteria (2008). Methods: Clinical data of malignant lymphoma from November 1st 2010 to March 31th 2015 in Affiliated Hospital of Academy of Military Medical Science were collected and reviewed, including morphological, immunological and clinical characteristics. All the cases were reappraised according to the WHO (2008) classification. Results: Of the 443 cases malignant lymphoma, Hodgkin’s lymphoma was 11.06% (49/443) and non-Hodgkin’s lymphoma was 88.94% (394/443). Among non-Hodgkin’s lymphoma, B cell lymphoma was 66.37% (294/443) and T cell lymphoma was 22.35% (99/443). The commonest subtypes were diffuse large B-cell lymphoma 41.53% (184/443), follicular lymphoma 11.06% (49/443), peripheral T-cell lymphoma 5.65% (25/443), T leukaemia/lymphoblastic lymphoma 5.19% (23/443), extranodal marginal zone B-cell lymphoma of MALT type 4.74% (21/443). Nodular sclerosis classical Hodgkin’s lymphoma was the commonest pathological type of Hodgkin′s lymphoma (4.51%, 20/443). The ratio of male to female was 1.58:1. The mean age at presentation was 57 years (range, 7~94 years). The lymph nodes of the cervical region were most commonly involved. The lymph nodes of the cervical region were most commonly involved. Conclusion: Of 443 cases of malignant lymphoma, diffuse large B-cell lymphoma is the commonest subtype of non-Hodgkin’s lymphoma, and Nodular sclerosis classical Hodgkin’s lymphoma is the commonest subtype of Hodgkin’s lymphoma. Most subtypes show a male predominance with most commonly affected in cervical lymphnodes.