乳腺癌中NGX6表达与BI-RADS超声特征及淋巴结转移的关系
| 作者: |
1刘梦涵,
1肖际东
1 中南大学湘雅三医院超声科，长沙 410013 |
| 通讯: |
肖际东
Email: jidongxiao1975@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2022.10.014 |
| 基金: | 湖南省自然科学基金(2019JJ40459)；湖南省卫生健康委科研课题(B2019177)。 |
摘要
Relationship of NGX6 expression with BI-RADS ultrasonographic features and lymph node metastasis in breast cancer
CorrespondingAuthor: XIAO Jidong Email: jidongxiao1975@126.com
DOI: 10.3978/j.issn.2095-6959.2022.10.014
Foundation: This work was supported by the Natural Science Foundation of Hunan Province (2019JJ40459) and the Project of Hunan Health Committee (B2019177), China.
Abstract
Objective: To investigate the relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis. Methods: Ultrasonic features and clinical data of 162 breast cancer cases were retrospectively collected and classified according to BI-RADS criteria. The expression of NGX6 in breast cancer tissues was detected by immunohistochemistry. The relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis was analyzed. Results: There were 92 (56.8%) NGX6 positive expressions and 70 (43.2%) NGX6 negative expressions in 162 breast cancers. Compared with the NGX6 positive group, the NGX6 negative group showed a higher incidence of abundant blood flow, lymph node metastasis, and higher BI-RADS ultrasound category. NGX6 expression was negatively correlated with the degree of tumor blood flow and BI-RADS ultrasound classification (P=0.043, P=0.020, P=0.005, respectively). Conclusion: NGX6, as a tumor suppressor gene, is associated with BI-RADS ultrasound classification and ultrasound biological features of breast cancer, and NGX6 expression level can reflect the biological behavior of breast cancer to some extent.