Objective: To explore the effect of family-integrated health education based on WeChat platform on asthma patients. Methods: A total of 112 asthma patients in Hai’an People’s Hospital from June 2018 to May 2021 were selected as research subjects, and randomly divided into a control group and an observation group with 56 cases in each group. The control group was given routine health education, and the observation group was combined with family-integrated health education based on WeChat platform. Both groups completed 4-week nursing intervention, and the self-management ability, treatment compliance, asthma control, and quality of life were compared between the 2 groups. Results: After half a year of intervention, the observation group had significantly higher scores for avoiding disease-inducing factors [(45.72±7.06) points], disease monitoring [(16.27±3.21) points], symptom recognition [(14.73±2.18) points], and taking medication as prescribed by doctors [(21.52±3.85) points] than the control group [(38.25±5.63) points, (12.06±1.63) points, (12.05±1.54) points, (18.33±3.31) points, all P<0.05], but the time of going to the doctor between the observation group [(10.74±2.13) points] and the control group [(9.26±2.17) points] had no significant difference (P>0.05). After 6 months of intervention, the overall treatment compliance and asthma control in the observation group were significantly better than those in the control group (both P<0.05). Symptoms [(32.26±5.37) points], psychological state [(28.41±4.62) points], stimulus response [(20.34±3.26) points], and physical and mental health attention score [(12.33±2.05) points] were higher than those in the control group [(28.41±4.93) points, (25.18±4.55) points, (25.36±3.87) points, (17.31±3.18) points, (11.06±1.72) points, all P<0.05]. Conclusion: Family-integrated health education based on WeChat platform can significantly improve patients’ self-management ability, treatment compliance, asthma control, and quality of life.