Objective: To explore the clinical and psychobehavioral characteristics of children with epilepsy and attention deficit hyperactivity disorder (ADHD). Methods: A total of 125 children with epilepsy treated in Hainan Anning Hospital from October 2019 to December 2021 were selected to screen and diagnose the incidence of common ADHD. According to the screening and diagnosis results of comorbid ADHD, they were divided into an epilepsy group (simple epilepsy) and a combined group (epilepsy and ADHD). Relevant data were collected and the clinical characteristics of the 2 groups were compared. The psychological and behavioral characteristics of the 2 groups were evaluated by using the Conners Parent Symptom Questionnaire (PSQ) score. Results: ADHD was detected in 125 children with epilepsy, accounting for 27.20% (34/125), and the type of ADHD was mainly attention deficit, accounting for 64.71% (22/34). In the combined group, 50.00% (17/34), 61.76% (21/34), 64.71% (22/34), and 52.94% (18/34) children with epilepsy onset age <3 years, epilepsy course ≥5 years, use of ≥2 kinds of antiepileptic drugs (AEDs), and uncontrolled epilepsy were significantly higher than 26.37% (24/91), 40.66% (37/91), 43.96% (40/91), and 31.87% (29/91) in the epilepsy group (all P<0.05). The PSQ score showed that the scores of conduct problems, learning problems, psychosomatic disorders, impulse hyperactivity, and hyperactivity index in the combined group were significantly higher than those in the epilepsy group (all P<0.05). Conclusion: It is not uncommon for children with epilepsy to suffer from ADHD. Most of these children have the clinical characteristics of early onset of epilepsy, long course of disease, combined use of multiple AEDs, and poor epilepsy control, and the psychological and behavioral problems such as conduct and learning are often more serious, which should be paid attention to clinically.