Objective: To investigate the effect of lumbar support on stone removal and complications in prone position percutaneous nephrolithotomy. Methods: A prospective analysis method was used to select 80 patients with prone position percutaneous nephrolithotomy who underwent percutaneous nephrolithotomy in the Wuxi No. 9 Hospital Affiliated to Soochow University and the First Affiliated Hospital of Soochow University from July 2018 to July 2021, and were randomly divided into 2 groups. Two groups, each with 40 cases. The control group used a lumbar pad during the entire operation, while the observation group used a lumbar pad when establishing a percutaneous renal channel and removed the lumbar pad at the beginning of lithotripsy. The surgical indicators, renal activity, postoperative stone clearance rate, surgical complications and quality of life were compared between the 2 groups. Results: The operation time and bleeding volume of the observation group were lower than those of the control group, and the incidence of complications was lower than that of the control group; The renal activity in the observation group was higher than that in the control group, and the stone clearance rate in stage I was higher than that in the control group; The scores of all dimensions of quality of life in the observation group were higher than those in the control group (all P<0.05). Conclusion: Removal of the lumbar pad during prone position percutaneous nephrolithotomy can expand the range of motion of the kidney, shorten the operation time, improve the rate of I stage stone clearance, reduce the occurrence of major intraoperative bleeding, and thus improve the quality of life.