Objective: To explore the effect of Caprini thrombosis risk assessment model combined with graded nursing intervention on venous thrombosis in patients after thoracoscopic lung cancer resection. Methods: A total of 136 patients with thoracoscopic lung cancer after resection in the First Affiliated Hospital of Xinjiang Medical University from January 2019 to August 2021 were selected and randomly divided into a control group and an observation group according to the random number table method, with 68 cases in each group. The control group was given routine nursing, and the observation group was graded according to the Caprini risk assessment model on the basis of routine nursing, and then given graded nursing according to risk level. The incidence of venous thromboembolism (VTE), postoperative recovery, nursing satisfaction, and levels of D-dimer and platelet count (PLT) before and after the operation were compared between the 2 groups. Results: The total incidence of VTE in the observation group was significantly lower than that in the control group (P<0.05). The maximum width of thrombosis in the observation group was significantly smaller than that in the control group (P<0.05). Compared with the control group, the chest tube indwelling time and hospitalization time in the observation group were significantly shorter, the activities of daily living (ADL) score was significantly higher, and the differences between the 2 groups were statistically significant (all P<0.05). The levels of D-dimer and PLT at 3 d after the operation in the observation group were significantly lower than those in the control group (all P<0.05). The scores of health education and guidance, personal characteristics and service attitude, service quality, and discharge guidance in the observation group were significantly higher than those in the control group (all P<0.05). Conclusion: Caprini thrombosis risk assessment model combined with graded nursing intervention can effectively prevent the occurrence of VTE in patients after thoracoscopic lung cancer resection, reduce postoperative D-dimer and PLT levels, promote postoperative recovery, and improve patient satisfaction with nursing.