Objective: To explore the effect of cognitive behavioral nursing based on information–motivation–behavioral skills (IMB) model on the psychological status of glaucoma patients. Methods: A total of 98 patients who underwent glaucoma surgery in Lu’an People’s Hospital of Anhui Province from September 2019 to September 2021 were selected as research subjects. According to the random number table method, the patients were divided into a study group and a control group, each with 49 cases. The control group received routine care, and the study group received cognitive behavioral care based on the IMB model on the basis of the control group. Before discharge, the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Exercise of Self-Care Agency (ESCA) score, intervention time of intraocular pressure, and nursing satisfaction of the 2 groups were compared. Results: After nursing, the SAS and SDS scores of the study group were significantly lower than those of the control group, and both groups were lower than those before nursing (all P<0.05); the scores of glaucoma knowledge, compliance, responsibility and skills in the study group were significantly higher than those in the control group (all P<0.05); nursing satisfaction and intraocular pressure intervention time in the study group were significantly higher/shorter than those in the control group (P<0.05). Conclusion: The application of cognitive-behavioral nursing based on the IMB model to glaucoma patients can significantly improve their psychological status, improve self-care ability, and shorten the time of intraocular pressure control, which is worthy of clinical promotion.