Alzheimer’s disease (AD), a neurodegenerative disease, is one of the main reasons leading to dementia. Curcumin, a polyphone compound, is an active yellow polyphenol pigment of turmeric. Curcumin has been attracted highly attention due to its outstanding safety profile and a number of pleiotropic actions with potential for neuroprotective effects. In recent years, it has been suggested that curcumin displays protective effect against the development of AD in vivo as well as in vitro. As an antioxidative agent, curcumin exerts the neuroprotective effect on AD through decrease in formation of reactive oxidative species and maintaining the balance of redox. In addition, it also exerts regulatory effects on signal molecules, such as NF-κB, β-amyloid precursor protein, β-site APP cleavage enzyme 1, and nuclear factor-erythroid 2-related factor 2.