Objective: To explore the intervention effect of cluster nursing in the treatment of children with bronchopneumonia by aerosol inhalation. Methods: A total of 106 hospitalized children with bronchopneumonia treated in the Pediatrics of Suzhou Hospital Affiliated to Anhui Medical University from August 2019 to September 2021 were selected. Patients who received routine nursing of atomization inhalation from August 2019 to July 2020 were included in the routine group (n=53). The cluster nursing intervention group was established from August 2020 to September 2021, and this group of patients who received the cluster nursing of atomization inhalation was recorded as the study group (n=53). The general data of the 2 groups were collected, and the relevant indexes of atomization inhalation compliance and treatment effect were compared between the 2 groups. Results: The disappearance time of cough, fever, pulmonary rales and hospital stay in the study group were shorter than those in the routine group (P<0.05). The number of crying in the study group was less than that in the routine group, and the treatment compliance rate was 94.34% higher than 81.13% in the routine group (P<0.05). After the intervention, the forced vital capacity (FVC), forced expiratory volume in the first second (FEV₁) and peak expiratory flow (PEF) in the 2 groups were significantly improved (P<0.05), and the above pulmonary function indexes in the study group were higher than those in the conventional group (P<0.05). Conclusion: Cluster nursing can improve the treatment compliance of atomization inhalation in children with bronchopneumonia, shorten the time of clinical symptom relief and hospitalization, and promote the improvement of pulmonary function.