Objective: To explore the effects of introducing failure mode and effects analysis (FMEA) in the management of postural placement during radical resection for lung cancer. Methods: A total of 120 patients undergoing radical lung cancer surgery in our hospital from March 2019 to March 2021 were selected and randomly divided into two groups. The control group received routine postural placement management, and the observation group introduced FMEA intervention in the management of body position placement and formulated improvement measures. The changes of blood pressure, airway pressure, heart rate and operation time, the incidence of complications related to the operation position, coagulation indexes and postoperative comfort were compared between the two groups before and after placement. Results: After placement, the diastolic blood pressure, systolic blood pressure, airway pressure, and heart rate of observation group were lower than those of the control group (P<0.05); the observation group had shorter operation time than the control group (P<0.05); the incidence of complications related to the surgical position of the observation group was lower than that of the control group (P<0.05); the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) of the observation group were higher than those of the control group at 1 h after the operation, and the fibrinogen (Fbg) was lower than that of the control group (P<0.05); postoperative comfort of the observation group was better than that of the control group (P<0.05). Conclusion: The introduction of FMEA in the management of postural placement in radical lung cancer surgery can shorten the operation time, identify and eliminate potential risks of patients, maintain intraoperative circulatory function, reduce the incidence of complications related to surgical position, improve blood coagulation indicators, and improve postoperative comfort.