Objective: To explore the predictive value of serum albumin (ALB), prealbumin (PA), hemoglobin (Hb) and urine β₂-microglobulin (β₂-mG) in different types of preeclampsia. Methods: A total of 91 patients with preeclampsia treated in our hospital from January 2018 to December 2020 were selected as the observation group. According to the relevant guidelines, they were divided into mild group (38 cases), early onset group (32 cases) and late onset group (21 cases), and 90 healthy pregnant women who underwent antenatal examination in our hospital in the same period were selected as the control group. The levels of serum ALB, PA, Hb and β₂-mG in pregnant women were compared. Logistic univariate and multivariate analysis was used to screen the risk factors of preeclampsia. ROC curve was used to analyze the predictive value of each indicator for different types of preeclampsia. Results: There were significant differences in serum ALB, PA and Hb levels between the observation group and the control group (P<0.05). The serum ALB, PA and Hb levels in observation group were lower than those in control group, while β₂-mG level was higher than that in control group. There were significant differences in serum ALB, PA, Hb and β₂-mG levels between different types of preeclampsia subgroups and control group (P<0.05). The results of pairwise comparison showed that the levels of ALB and β₂-mG in mild group, early-onset group, late-onset group and control group were significantly different (P<0.05). The level of PA in early-onset group was significantly higher than that in late-onset group and control group, and the level of PA in late-onset group was significantly lower than that in mild group, with statistical significance (P<0.05). The Hb level in the mild group was significantly lower than that in the early-onset group, late-onset group and control group, and the Hb level in the late-onset group was significantly higher than that in the mild group, with statistical significance. According to logistic univariate and multivariate analysis, low serum ALB and Hb levels and high serum β₂-mG levels were risk factors for mild preeclampsia (P<0.05). Low serum ALB level and high serum β₂-mG level were risk factors for early onset severe preeclampsia (P<0.05). Low levels of ALB and PA and high levels of β₂-mG were risk factors for late onset severe preeclampsia (P<0.05). The area under ROC curve of serum ALB, PA, Hb and β₂-mG for predicting mild preeclampsia, early-onset severe preeclampsia and late-onset severe preeclampsia were 0.854, 0.933 and 0.994, respectively. The sensitivities were 94.38%, 92.13% and 98.88%, respectively. The specificities were 60.53%, 78.13% and 95.24%. Conclusion: The levels of serum ALB, PA, Hb and β₂-mG have good predictive value in early-onset and late-onset severe preeclampsia, which is worth popularizing and implementing in clinic.